Dear BB,

Please forward to any potential PhD applicants.

Thanks
Ed



PhD studentship in Structural Molecular Biology in collaboration with AstraZeneca.
Part of an integrated approach to discovering cell-permeable inhibitors of alpha helix-mediated protein-protein
interactions.

See
http://www.bmb.leeds.ac.uk/staff/tae/AZ_Studentship_inStrucBiol_Ad.pdf
For details.


Supervisory team:
Dr Thomas Edwards, Dr Andy Wilson, Professor Adam Nelson and Dr Stuart Warriner.

Protein−protein interactions (PPIs) mediate many biological mechanisms,
and, potentially, represent exciting targets for the treatment of disease.
Although small molecule inhibitors of a few PPIs have been discovered,
the principles that underpin the discovery of such ligands, within the
boundaries of drug-like chemical space, are much less well established
than for conventional medicinal chemistry targets such as enzymes and
receptors. In addition, it is unlikely, for example, that current small
molecule collections are honed for screening against PPIs.
We will target three contrasting α-helix mediated PPIs of strategic interest
to AZ. The proposed programme will integrate the combined expertise of
the team at Leeds (and our collaborators at AZ) in the synthesis of both
helix mimetics, and small molecules of unprecedented scaffold diversity,
in combination with cutting edge structural biology.

The studentship will start by October 1st 2011 and the stipend
would be at the standard research council rate (~ £13,895 pa
for 2011/12). Applications, for this 3.5 year studentship which
will be accepted until the studentship is filled, should be
directed to Anna Luty, School of Chemistry, University of Leeds, Leeds LS2 9JT and can be made
online via the following link: http://www.chem.leeds.ac.uk/postgraduate-research/how-to-apply.html

Please contact Dr Thomas Edwards ([log in to unmask]) or Dr. Andy Wilson
([log in to unmask]) for further details about this project.

UK Research Council eligibility rules apply.


______________
T.Edwards Ph.D.
Garstang 8.53d
Astbury Centre for Structural Molecular Biology
University of Leeds, Leeds, LS2 9JT
Telephone: 0113 343 3031
http://www.bmb.leeds.ac.uk/staff/tae/
-- There is something fascinating about science.  One gets such wholesale returns of conjecture out of such a trifling investment of fact.  ~Mark Twain