Dear Eugene, thanks so much for your help, hopefully this is my last message on this little project. I have set up the model according to how I think you explained, and I get an error about linear combination. Could you please look at this and see where I've gone wrong? Again, I have 12 in each group, 3 types of scans. The first 36 inpouts are group 1, and last 36 group 2. The first column is the group difference, the next three columns model scan 1 vs 2, scan 1 vs 3, and scan 2 vs 3. Then the next 22 columns model out individual averages as I think you suggested. The last 3 columns are the interactions. Thanks very much, Katie
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