Thank you for your response.
Next question - how is the time 1 - time 2 information coded in the design matrix? We have been trying to follow the practicum examples be we are having difficulty.
Thanks for your help.
Julie
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From: FSL - FMRIB's Software Library [[log in to unmask]] On Behalf Of Stephen Smith [[log in to unmask]]
Sent: Tuesday, December 21, 2010 4:32 AM
To: [log in to unmask]
Subject: Re: [FSL] SIENAr vs FSL-VBM
Hi - I would try it with both tools (SIENAr and FSLVBM). The former *may* give more sensitivity to small changes in overall brain size, but the latter *may* give better specificity about where the effect is, and possibly better sensitivity to effects happening in certain parts of the brain.
Cheers.
On 20 Dec 2010, at 21:40, Dumas, Julie A. wrote:
Hello. We have designed and run the following study. We have 2 groups of 12 women. Each woman was scanned 2 times. We hypothesize that the group that had drug treatment would have an increase in gray matter density.
What do you recommend as the better way to do a VBM analysis that can take into account our repeated measure across time, SIENAr or FSL-VBM?
Also we have had trouble constructing a design matrix that incorporates the time factor. Can you assist us in creating an appropriate design matrix for this study?
Thanks for your help.
Julie
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Stephen M. Smith, Professor of Biomedical Engineering
Associate Director, Oxford University FMRIB Centre
FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK
+44 (0) 1865 222726 (fax 222717)
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