Dear all
I wish to perform a "secondary" analysis on data collected in a
multicase-control design (where the primary aim was to investigate the
association between genetic determinants and respiratory diseases).
My aim is to study the association between the case-control status (main
independent covariate) and a continuous measure of exercise capacity
(dependent covariate), while adjusting for several potential confounders
(gender, age, smoking status, etc). I am currently using a standard
linear multiple regression model with exercise capacity = Y and the
case-control status and the other potential confounders as Xi.
Do you think that the above statistical analysis is correct, and do you
have any reference to support that?
I have found some reference on re-using data from case-control studies
by logistic regression (1,2), but no reference to the use of linear
regression models.
References:
1) Lee AJ, McMurchy L, Scott AJ. Re-using data from case-control
studies. Stat Med. 1997 Jun 30;16(12):1377-89.
2) Nagelkerke NJ, Moses S, Plummer FA, Brunham RC, Fish D. Logistic
regression in case-control studies: the effect of using independent as
dependent variables. Stat Med. 1995 Apr 30;14(8):769-75.
Best wishes to all!
Alessandro Marcon
--
Alessandro Marcon, PhD
Unit of Epidemiology& Medical Statistics
Department of Public Health and Community Medicine
University of Verona
Strada Le Grazie 8, 37134 Verona, Italy
tel. +39 045 8027668 fax +39 045 8027154
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