Hi Liu,
If I understand your question correctly, youre asking "how different
do two structures need to be for one to be "new'". If by "new" you
mean a new fold, then the answer is NO. Your structure and the homolog
have the same fold.
However, if your structure is the first structure of a protein in a
new class, then your structure is a new insight for that reason (e.g.
it is the first structure of a Unobtainium-metalloprotease).
If it is not the first structure of a protein from a new class, lets
say a previous structure of Unobtainium-metalloprotease has been
solved using H. sapiens' sequence, but your protein is the first D.
melanogaster ortholog solved, then your structure is a new insight for
that reason.
So, in a nut-shell, I guess what I am saying is that your protein is
not a new fold, but is almost certainly "new" by some qualification,
and you will know best what that qualification is. I hope that helps,
cheers and happy holidays~
~Justin
> On 20/12/2010 10:49, <Liu Zhao > wrote:
>> The structure of my protein is as shown as the purple one. Another one
>> ,as shown as green,is homologous .But the structure of my protein can't
>> be obtained by using molecular replacement. And both structures have
>> much different, especially in B chain. If my structure is a new one?
>> thank you for help.
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