Hello,
> is there any evidence that one of the two approaches (average vs matched
> pairs) in TOM8 is better than the other?
Hard evidence, no. Soft advice, yes :)
> I suppose it depends on the set of volumes you want to study...
Indeeed. The rationale behind implementing both approaches was that the
average approach would seem to be perfectly fine for a good-sized group
that is nicely distributed, in terms of age and gender. In the case of a
smaller group that may have outliers, the mean (being susceptible to
outliers) age/gender composition may not be a good reflection of the
group anymore. In that case, the matched pairs approach should yield a
better approximation.
Hope this helps,
Marko
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Marko Wilke (Dr.med./M.D.)
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Universitäts-Kinderklinik University Children's Hospital
Abt. III (Neuropädiatrie) Dept. III (Pediatric neurology)
Hoppe-Seyler-Str. 1, D - 72076 Tübingen
Tel.: (+49) 07071 29-83416 Fax: (+49) 07071 29-5473
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