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ALLSTAT  November 2010

ALLSTAT November 2010

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Subject:

Re: Nutt, King & Phillips, Lancet 2010, 376, 9752, 1558 - 1565

From:

Robert Newcombe <[log in to unmask]>

Reply-To:

Robert Newcombe <[log in to unmask]>

Date:

Fri, 5 Nov 2010 10:05:20 +0000

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (144 lines)

The key issue appears to be the statement in the paper 'MCDA distinguishes 
between facts and value judgments about the facts'. The process that was 
performed here appears to depend on 'expert opinion' alone, at every stage 
of the process - deciding what are the relevant outcomes, weighting them 
for their relative importance, and also rating different drugs with regard 
to these outcomes. It is appropriate for the first two of these steps to 
be driven by elicited opinion. But the third step should if at all 
possible be closer to being directly data-driven, not just rely on the 
opinions of experts who have seen the evidence.  It is at this point in 
the process that their arguments appear to be vulnerable. I realise that 
it would be naive to imagine that doing all this in an objective way would 
be as straightforward as conducting a Cochrane review on a well-defined 
issue. That process is now regarded as reasonably straightforward only 
because it has been done so many times, and experience has been gained. 
But surely we now have a better idea than this of how to make that third 
step data-driven. 

Robert G. Newcombe PhD CStat FFPH
Professor of Medical Statistics
Department of Primary Care and Public Health
Centre for Health Sciences Research
Cardiff University
4th floor, Neuadd Meirionnydd
Heath Park, Cardiff CF14 4YS

Tel: (+44) 29 2068 7260
Fax: (+44) 29 2068 7236

Home page https://sites.google.com/site/robertgnewcombe/home





From:   "Ameen J (AT)" <[log in to unmask]>
To:     [log in to unmask]
Date:   04/11/2010 21:36



The strength of this paper is in its simplicity, not to forget what 
Einstein had said "Keep it Simple (KIS)".That is what modelling is mainly 
about.  We are yet to learn about the complexity of our surroundings and 
the creation of miniture, simple and easy to understand models that can 
help us better understand these complex phenomena are all welcome. 
However, my comments (Ameen 1995) on a paper by Professor Chatfield are 
still valid. Models are subjective and some models are better than some 
others.  There is no "true" model!  It is not clear what the authors mean 
by stating "accuracy of individuals judgments..."!  in their use of a 
version of Visual Analogue Scale (VAS) or a ratio scale as the authors 
call it.  The benefits of the use of such a scale are stated in a paper 
(Coll and Ameen 2004) while the use of a four scale scoring limits its 
statistical use and induces biasedness as comparison with normality 
becomes difficult.  In terms of bisedness, I would have liked to read much 
more about the nature and the format of the pannel to ensure unbisedness.

Another point that I would like to make is the georeferencing of the 
experiment and the findings which would, to a degree, devalue the 
universal scientific content of the paper.  For example, the economic 
impact in pricing, costs and social acceptance of drugs.

Best wishes

Jamal

Coll AM, Ameen JRM & Mead D (2004).  Postoperative pain assessment tools 
in day surgery: literature review.  Journal of Advanced Nursing. 46(2), 
124-133;
Ameen JRM (1995) Comments on Model Uncertainty, Data Mining and 
Statistical Inference. J. R. Statist. Soc. A. 453

Prof Jamal Ameen
Senior Advisor, Ministry of Planning
KRG, Erbil
Tel: +496(750) 428 84 82
Email: [log in to unmask]
&
Faculty of Advanced Technology
University of Glamorgan, UK
http://staff.glam.ac.uk/users/3851-jrmameen

________________________________________
From: A UK-based worldwide e-mail broadcast system mailing list 
[[log in to unmask]] on behalf of Maria Viskaduraki 
[[log in to unmask]]
Sent: Thursday, November 04, 2010 1:32 PM
To: [log in to unmask]

I did read the paper. The moral for me: Choose a controversial subject and 
you can get through to a top journal.
The art of statistics is a separate story.

Maria Viskaduraki
Biostatistician
Birmingham


-----Original Message-----
From: A UK-based worldwide e-mail broadcast system mailing list [
mailto:[log in to unmask]] On Behalf Of Tony Greenfield
Sent: 04 November 2010 12:18
To: [log in to unmask]
Subject: nutt

to those allstatters who have read David Nutt's paper in the current 
Lancet:



I cannot believe that this was peer reviewed.



what to do you think?



Tony Greenfield

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