Please check the "project directory" & "temporary directory" is correct or not. Initially I faced the same problem for not assigning the correct project directory (I use it Windows, but the problem also occured in Linux system). If you are running CCP4 in Windows make sure that the folder "CCP4 DATABASE" contains 2 .DEF files -1. database & 2. tmp_database & also assign correct directories. For Linux,check the directories.
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