Hello FSL Experts,
I have used SIENA (sienax <T1_image> -o <output_name> -B 88 85 149) to capture ICV in several subjects and have found an unexpected relationship between age and ICV (a strong inverse relationship with ICV decreasing as age increases). I typically would not expect to observe such a relationship (unless my older subjects have smaller heads), so I was wondering if my methodology was correct (sienax <T1_image> -o <output_name> -B 88 85 149)? A more likely scenario might be a decrease in brain volume with age, but I was under the impression that when I multiplied the total brain volume by the VSCALING factor, that I was capturing ICV. Is this correct?
Some of the captured ICV values are listed below.
Cheers!
ICV Age
1519642.91 62.92
1372345.71 69.83
1566289.91 61.08
1381052.66 68.33
1498448.09 58.83
1437447.51 67
1500638.8 69.33
1413323.2 76.08
1668326.34 61.42
1626539.29 65.25
1520028.79 68.83
1439787.42 77.42
1367213.24 75.5
1462530.25 76.83
1392069.23 82.25
1391631.46 83.5
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