Dear All,
We have diffusion and structural data in single patients with unique genetic abnormalities. What would be the best way to statistically compare single subjects against a group of a controls (eg 20 to 30) using methods like TBSS.
I have seen previous postings on this subject: eg
https://www.jiscmail.ac.uk/cgi-bin/webadmin?A2=FSL;lpOogA;20071129133107%2B0000
My question was whether the approach of creating difference images (each control - patient) and then running randomise and a 1 sample t-test on the difference images is a valid approach. I have seen something similar used in fMRI analyses.
Thanks.
Mahinda
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