Hi -
You should not use literature as proof; every protein is different.
You would need to do site directed mutagenesis experiments,
to show which binding mode is relevant.
I am also not sure what 'completely different' means, if the ligands
are in different sites,
it could also be of interest, eg an allosteric effect.
A.
On 17 May 2010, at 4:20, <Rain Field> <[log in to unmask]> wrote:
> Thank you for your valuable advice.
> My situation is this:
> I got two completely different structures by soaking and co-
> crystallization.
> I believe co-crystallization. But I don't know if I can find the
> literature which I would cite as a proof.
>
> Rain Field
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