CCP4BB automatic digest system <[log in to unmask]> wrote:
>There are 20 messages totaling 5953 lines in this issue.
>
>Topics of the day:
>
> 1. Help with Bayes's theorem (4)
> 2. programmatic symmetry mate generation
> 3. <No subject given>
> 4. Sonication e.coli parameters
> 5. X-Ray films
> 6. X-Ray films [SEC=UNCLASSIFIED] (2)
> 7. Substitute for Lithium Sulfate (2)
> 8. PhD position in structural biology - Bordeaux - France
> 9. Protein topology plot (2)
> 10. Postdoctoral Fellowship in Membrane Protein Crystallography in Houston
> 11. Crystal Positioning System Pucks - Tested
> 12. Crystallography Near Venice/Padova Italy (3)
>
>----------------------------------------------------------------------
>
>Date: Mon, 26 Apr 2010 16:03:40 -0700
>From: James Stroud <[log in to unmask]>
>Subject: Re: Help with Bayes's theorem
>
>Bayes Theorem can help well informed patients too. They just need to
>know how good their doctors are!
>
>1. After reading the NYT you know that 1/3 of the time your doctor is
>going to tell you that you have better than a 90% chance of breast
>cancer if you have a positive mammogram.
>2. After reading the NYT, you know that 0.8% of women your age get
>breast cancer.
>2. After a chat at the hair salon, you were surprised to learn that
>about 2.5% of women who had mammograms and don't have breast cancer
>were needlessly scared shitless when their doctors told them they had
>a 90% chance of having breast cancer.
>3. You take a mammogram and your doctor tells you that you have a 90%
>chance of breast cancer.
>
>What is your real chance of breast cancer after this mammogram?
>
>p(H|E) = (pH * pE|H) / pE = (pH * pE|H) / (pH * pE|H + pE|H' * pH')
> = (0.008 * 1/3) / ((0.008 * 1/3) + (0.025 * 0.992))
> = 9.4%
>
>Who needs an MD?
>
>James
>
>
>On Apr 26, 2010, at 12:30 PM, Jim Pflugrath wrote:
>> I'm always on the lookout for good ways to teach
>> Bayes's theorem.
>
>------------------------------
>
>Date: Mon, 26 Apr 2010 16:21:43 -0700
>From: Eric Pettersen <[log in to unmask]>
>Subject: Re: programmatic symmetry mate generation
>
>Hi James,
> The symmetry copies of a molecule asymmetric unit can be saved to a
>new PDB file using the saveunitcell.py Python script with Chimera.
>
> http://plato.cgl.ucsf.edu/trac/chimera/wiki/Scripts
>
>It uses the CRYST1 record in the PDB file to determine the symmetry
>group. Unfortunately as mentioned in the script you need to use
>Chimera as the Python interpreter, which you may not be willing to do
>-- but you can just call out to the command-line version of Chimera
>(also documented in the script) via os.system() or whatnot.
> There is also a sym command in Chimera which can generate symmetry
>mates from a wide spectrum of possible criteria. A Python script to
>call sym is just:
>
>from chimera import runCommand
>runCommand("sym <options you want>")
>
>--Eric
>
> Eric Pettersen
> UCSF Computer Graphics Lab
> http://www.cgl.ucsf.edu
>
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 08:11:31 +0530
>From: Dhabaleswar Patra <[log in to unmask]>
>Subject: <No subject given>
>
>Dhabaleswar Patra
>M.Vijayan's Lab
>Molecular Biophysics Unit
>Indian Institute Of Science
>Bangalore,Karnataka-560012
>Mobile- +919980369860
>
>
>--
>This message has been scanned for viruses and
>dangerous content by MailScanner, and is
>believed to be clean.
>
>------------------------------
>
>Date: Mon, 26 Apr 2010 21:01:30 -0700
>From: megha goyal <[log in to unmask]>
>Subject: Sonication e.coli parameters
>
>Hi All,
>
>Our protein is expressed as inclusion bodies ibn e.coli W3110 cells. we
>harvest the cells supend it in water [no buffer] and perform sonication to
>lyse the cells. we lyse the cells till our O.D is decreased to 1/3rd of
>original our starting O.D of suspension is about 250. then we centrifuge the
>abvoe suspencion at 12000 rpm to collect teh inclusion bodies. but we are
>not getting good yield and also inclusion bodies are not that pure. Do we
>need to add lysozyme prior to lysis. can anyone suggest a good method to
>lyse ecoli cells expressing protein in inclusion bodies.
>
>Thanks in anticipation
>
>meg
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 08:53:23 +0200
>From: Flip Hoedemaeker <[log in to unmask]>
>Subject: Re: X-Ray films
>
>Indiana Jones and the Kingdom of the Crystal Skull?
>"Nothing shocks me, I'm a scientist".
>
>Flip
>
>harry powell wrote:
>> Hi
>>
>> Not a question about films for recording X-rays on, but a question about
>> films about X-rays, Crystallography and related subjects!
>>
>> I was wondering what ccp4bbers favourite movies involving real science,
>> especially crystallography might be? If they're from Hollywood, though,
>> I'd guess it should be "favorite"...
>>
>> I'm a little tired, but the only one I can think of at the moment is
>> actually based on results from fibre diffraction - "Life Story", with
>> Jeff Goldblum. There must be others, though.
>>
>> Harry
>> --
>> Dr Harry Powell,
>> MRC Laboratory of Molecular Biology,
>> Hills Road,
>> Cambridge,
>> CB2 0QH
>>
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 16:59:42 +1000
>From: "DUFF, Anthony" <[log in to unmask]>
>Subject: Re: X-Ray films [SEC=UNCLASSIFIED]
>
>At the other end, featuring at one stage giant diamonds (carbon
>crystallised in magma) is "The Core (2003)", which someone described as
>a movie designed to annoy all scientists as much a possible.
>
>Anthony
>Anthony Duff Telephone: 02 9717 3493 Mob: 043 189 1076
>
>
>harry powell wrote:
>> Hi
>>
>> Not a question about films for recording X-rays on, but a question
>about
>> films about X-rays, Crystallography and related subjects!
>>
>> I was wondering what ccp4bbers favourite movies involving real
>science,
>> especially crystallography might be? If they're from Hollywood,
>though,
>> I'd guess it should be "favorite"...
>>
>> I'm a little tired, but the only one I can think of at the moment is
>> actually based on results from fibre diffraction - "Life Story", with
>> Jeff Goldblum. There must be others, though.
>>
>> Harry
>> --
>> Dr Harry Powell,
>> MRC Laboratory of Molecular Biology,
>> Hills Road,
>> Cambridge,
>> CB2 0QH
>>
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 17:05:00 +1000
>From: "DUFF, Anthony" <[log in to unmask]>
>Subject: Re: X-Ray films [SEC=UNCLASSIFIED]
>
>For minimum offense of the science, Contact (1997) was good.
>
>Anthony
>Anthony Duff Telephone: 02 9717 3493 Mob: 043 189 1076
>
>
>-----Original Message-----
>From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of
>DUFF, Anthony
>Sent: Tuesday, 27 April 2010 5:00 PM
>To: [log in to unmask]
>Subject: Re: [ccp4bb] X-Ray films [SEC=UNCLASSIFIED]
>
>At the other end, featuring at one stage giant diamonds (carbon
>crystallised in magma) is "The Core (2003)", which someone described as
>a movie designed to annoy all scientists as much a possible.
>
>Anthony
>Anthony Duff Telephone: 02 9717 3493 Mob: 043 189 1076
>
>
>harry powell wrote:
>> Hi
>>
>> Not a question about films for recording X-rays on, but a question
>about
>> films about X-rays, Crystallography and related subjects!
>>
>> I was wondering what ccp4bbers favourite movies involving real
>science,
>> especially crystallography might be? If they're from Hollywood,
>though,
>> I'd guess it should be "favorite"...
>>
>> I'm a little tired, but the only one I can think of at the moment is
>> actually based on results from fibre diffraction - "Life Story", with
>> Jeff Goldblum. There must be others, though.
>>
>> Harry
>> --
>> Dr Harry Powell,
>> MRC Laboratory of Molecular Biology,
>> Hills Road,
>> Cambridge,
>> CB2 0QH
>>
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 09:17:08 +0200
>From: [log in to unmask]
>Subject: Re: Substitute for Lithium Sulfate
>
>Dear Lucas,
>
>A long time ago, I ran into the same problem and in this case we were
>able to replace ammonium sulfate by non-ionic precipitants like PEG
>while keeping diffraction. Since it seems that the paper we wrote about
>it is difficult to access online, I have attached the pdf. It gives you
>an idea about the experiments you could try. At that time, even with PEG
>we were not succesful in soaking in our ligand. However, recently with
>an in-house project we were successful with the method, so I can
>recommend it. Today, I would use a slightly higher than equilibrium PEG
>concentration, to stabilize and dehydrate the crystal a little, which
>may improve diffraction.
>
>Good luck!
>Herman
>
>
>________________________________
>
> From: CCP4 bulletin board [mailto:[log in to unmask]] On
>Behalf Of Yi-Liang Liu
> Sent: Friday, April 23, 2010 7:53 PM
> To: [log in to unmask]
> Subject: [ccp4bb] Substitute for Lithium Sulfate
>
>
> Hi Everyone,
>
>
> I have a question about the crystallization condition. Currently
>the condition I use contains 0.2M lithium sulfate. However, the ligand
>there seems to compete the site where sulfate binds in the active site.
>Are there any good substitute to replace the Lithium sulfate in my
>crystallization buffer?
>
> Best,
>
> Lucas
>
>
>
>
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 11:08:54 +0100
>From: Colin Nave <[log in to unmask]>
>Subject: Re: Help with Bayes's theorem
>
>
>This is quite a good one as well
>http://www.inference.phy.cam.ac.uk/mackay/pope.html
>
>I recall the pope analysis followed on from a Nature article covering
>the O J Simpson example (also covered in the NY times link).
>
>Sean Eddy who is an author on the above link wrote what I regard as an
>excellent intro to Bayesian statistics
>ftp://selab.janelia.org/pub/publications/Eddy-ATG3/Eddy-ATG3-reprint.pdf
>Colin
>
>> -----Original Message-----
>> From: CCP4 bulletin board [mailto:[log in to unmask]] On
>> Behalf Of Jim Pflugrath
>> Sent: 26 April 2010 20:30
>> To: [log in to unmask]
>> Subject: [ccp4bb] Help with Bayes's theorem
>>
>> I thought some of you would enjoy a little conditional
>> probability discussion found in the NY Times today, since
>> this is a big part of crystallography nowadays. I'm always
>> on the lookout for good ways to teach Bayes's theorem.
>>
>> http://opinionator.blogs.nytimes.com/2010/04/25/chances-are/
>>
>> Jim
>>
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 15:11:26 +0200
>From: Bernard Gallois <[log in to unmask]>
>Subject: PhD position in structural biology - Bordeaux - France
>
>PhD POSITION IN STRUCTURAL BIOLOGY - BORDEAUX – FRANCE.
>
>Protein-protein interactions are a central issue in biological
>processes, and represent relevant therapeutic targets for the treatment
>of many diseases. The design of antagonistic molecules directed towards
>the disruption of these interactions requires the specific recognition
>of important protein surfaces. Aromatic oligomers present all the
>properties (high functionalization, stability and easy predictability of
>the structure, length flexibility) to reach that point.
>The thesis will be devoted to the optimization of the design of
>quinoline-derived aromatic amide foldamers (see
>http://www.iecb.u-bordeaux.fr/teams/HUC/), using structural tools (X-ray
>diffraction, molecular modelling). It lies within the scope of a
>european multidisciplinary project associating private sector
>(UCB-Pharma, Belgium) and universities (Bordeaux, Wurzburg). The
>proteins which will be used as a basis for this study have been chosen
>according to their therapeutic relevance. They crystallize easily and
>the interaction geometry between each partner is perfectly known.
>The crystallization of the aromatic oligomers tethered to the protein
>and their structure determination will be led in close cooperation with
>the private sector, which will imperatively welcome the student during
>the twelve months of his PhD second year. The chemical synthesis and the
>evaluation of the physicochemical properties of the studied molecules
>will be approached by the partner groups. A background in structural
>biology and some concepts in crystallography are strongly wished.
>
>KEYWORDS: protein-protein interactions, aromatic oligomers, protein
>crystallography, protein foldamer complexes, protein surface recognition
>
>PROFILE*: *Biologists and/or biochemists with a background in structural
>biology are strongly encouraged to postulate. Additional experience in
>protein crystallography and X-rays diffraction would be an asset.**
>
>APPLICATIONS* *(including CV, research experience, and two names and
>contact information for references) should be sent to
>[log in to unmask] Successful candidates will be interviewed
>in Bordeaux early in July and will be expected to join the program in
>September 2010.
>
>--
>****************************************************************
>Bernard Gallois
>UMR CNRS 5248 - Chimie et Biologie des Membranes et Nano-objets (C.B.M.N)
>-------------------------------
>Université Bordeaux I
>Avenue des Facultés, Bât. B8,
>33405 - Talence Cedex
>France
>-------------------------------
>tel: 33 (0)5 40 00 24 52
>fax: 33 (0)5 40 00 22 00
>e-mail: [log in to unmask]
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 13:22:36 +0000
>From: Klaus Sengstack <[log in to unmask]>
>Subject: Protein topology plot
>
>Hi everybody,
>
>I´m looking for a program to generate a topology plot of a β-propeller fold. The server for "Topdraw" seems not to work anymore. Can anybody recommend another server/program?
>
>Best regards.
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 07:40:38 -0700
>From: Ethan Merritt <[log in to unmask]>
>Subject: Re: Protein topology plot
>
>On Tuesday 27 April 2010, Klaus Sengstack wrote:
>> Hi everybody,
>>
>> I´m looking for a program to generate a topology plot of a β-propeller fold. The server for "Topdraw" seems not to work anymore.
>
>The source and scripts to run topdraw are included in the ccp4i
>directories. You can run them directly from your desktop.
>Or, if you prefer, from the "Graphics and Viewing Utilities"
>menu in ccp4i.
>
> Ethan
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 10:04:18 -0600
>From: Michel Fodje <[log in to unmask]>
>Subject: Re: Help with Bayes's theorem
>
>The opinionator piece is misleading about the meaning of probability, especially as it implies that you could reformulate every problem into one about frequencies. As was pointed out a long time ago by Harold Jeffreys and repeated by Ed Jaynes,
>
>"The essence of the present theory is that no probability, direct, prior, or posterior, is simply a frequency" -- H. Jeffreys (1939)
>
>"... a probability is a theoretical construct, on the epistemological level, which we
>assign in order to represent a state of knowledge, or that we calculate from other probabilities according to the rules of probability theory. A frequency is a property of the real world, on the ontological level, that we measure or estimate. So for us, probability theory is not an Oracle telling how the world must be; it is a mathematical tool for organizing, and ensuring the consistency of, our own reasoning." -- E.T. Jaynes[1]
>
>There are lots of simple problems you will not be able to reason correctly if you assume a probability is a frequency (e.g. Bernoulli's Urn). Not every event can be repeated a large number of times such that a frequency is obtained. This difficulty has often pushed "frequentists", to be confused between the result of measuring one thing many times and the result of measuring many things one time. For example, one could ask, by what basis do you draw a conclusion from the few that were surveyed to the millions that were not?
>
>Monitoring 1000 women and finding that 0.8% of them get breast cancer, tells you nothing about the health of the patient standing in front of you! Unless you have some other prior information linking the one to the one-thousand. What is really relevant would be to measure the one patient many times, but this is not always possible.
>
>I find that Jaynes book on Probability Theory[2] is THE definitive guide on how to teach it. For the less mathematically inclined, Chapter 1, which is freely available[3] online as a PDF is very readable and eye-opening.
>
>[1] Jaynes, E. T., 1989, `Clearing up Mysteries - The Original Goal, ' in Maximum-Entropy and Bayesian Methods, J. Skilling (ed.), Kluwer, Dordrecht, p. 1;
>
>[2] http://www.amazon.com/Probability-Theory-Logic-Science-Vol/dp/0521592712
>
>[3] http://bayes.wustl.edu/etj/prob/book.pdf
>
>
>-----Original Message-----
>From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Colin Nave
>Sent: April-27-10 4:09 AM
>To: [log in to unmask]
>Subject: Re: [ccp4bb] Help with Bayes's theorem
>
>
>This is quite a good one as well
>http://www.inference.phy.cam.ac.uk/mackay/pope.html
>
>I recall the pope analysis followed on from a Nature article covering
>the O J Simpson example (also covered in the NY times link).
>
>Sean Eddy who is an author on the above link wrote what I regard as an
>excellent intro to Bayesian statistics
>ftp://selab.janelia.org/pub/publications/Eddy-ATG3/Eddy-ATG3-reprint.pdf
>Colin
>
>> -----Original Message-----
>> From: CCP4 bulletin board [mailto:[log in to unmask]] On
>> Behalf Of Jim Pflugrath
>> Sent: 26 April 2010 20:30
>> To: [log in to unmask]
>> Subject: [ccp4bb] Help with Bayes's theorem
>>
>> I thought some of you would enjoy a little conditional
>> probability discussion found in the NY Times today, since
>> this is a big part of crystallography nowadays. I'm always
>> on the lookout for good ways to teach Bayes's theorem.
>>
>> http://opinionator.blogs.nytimes.com/2010/04/25/chances-are/
>>
>> Jim
>>
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 12:16:28 -0400
>From: Ed Pozharski <[log in to unmask]>
>Subject: Re: Substitute for Lithium Sulfate
>
>Transferring crystal into mother liquor minus lithium sulfate plus
>ligand may work (consider both direct and stepwise transfer). Worked
>for us recently when 0.2M sodium malonate was competing out the ligand
>(which is ironic given that sodium malonate would be my first choice of
>replacing ammonium sulfate when it is major precipitant, see Holyoak et
>al., Acta Cryst D59:2356).
>
>HTH,
>Ed.
>
>On Fri, 2010-04-23 at 12:53 -0500, Yi-Liang Liu wrote:
>> Hi Everyone,
>>
>> I have a question about the crystallization condition. Currently the
>> condition I use contains 0.2M lithium sulfate. However, the ligand
>> there seems to compete the site where sulfate binds in the active
>> site. Are there any good substitute to replace the Lithium sulfate in
>> my crystallization buffer?
>>
>>
>> Best,
>>
>>
>> Lucas
>>
>>
>>
>
>
>--
>Edwin Pozharski, PhD, Assistant Professor
>University of Maryland, Baltimore
>----------------------------------------------
>When the Way is forgotten duty and justice appear;
>Then knowledge and wisdom are born along with hypocrisy.
>When harmonious relationships dissolve then respect and devotion arise;
>When a nation falls to chaos then loyalty and patriotism are born.
>------------------------------ / Lao Tse /
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 11:35:35 -0500
>From: "Spudich, John L" <[log in to unmask]>
>Subject: Postdoctoral Fellowship in Membrane Protein Crystallography in Houston
>
>A Postdoctoral fellowship is available to study the structure and function of microbial sensory rhodopsins. The position requires a recent Ph.D. in one of the natural sciences relevant to structural biochemistry. Applicants must be highly motivated and must have demonstrated experience (i.e. relevant publications) with 3D protein structure determination, especially recombinant protein expression, purification, and crystallization. Experience with membrane proteins is an advantage. Salary will be commensurate with experience and will be in addition to a fringe benefit package. Our laboratory in the Center for Membrane Biology, Department of Biochemistry & Molecular Biology, University of Texas Medical School at Houston is fully equipped for molecular biology, protein chemistry, and protein crystallography. In addition, our University is part of the Molecular Biology Consortium that operates its own high flux MAD-capable x-ray beamline at ALS Berkeley, California. Apply to [log in to unmask]<mailto:[log in to unmask]> , Professor and Director, Center for Membrane Biology, including your CV, statement of research interests, and names of 3 references.
>
>This email is valid until May 31, 2010.
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 12:24:38 -0500
>From: Cyndi Salbego <[log in to unmask]>
>Subject: Crystal Positioning System Pucks - Tested
>
>NE-CAT (MX beamlines at APS) placed an order and tested pucks from http://www.crystalpositioningsystems.com/ and found that they worked well! We would definitely recommend that this be considered as a source for ALS style pucks.
>
>These pucks were used with this setup that we have:
>
>http://necat.chem.cornell.edu/~perry/
>
>Crystal Positioning Systems contact info can be found on their website.
>
>
>
>Cyndi Salbego
>http://necat.chem.cornell.edu/index.htm
>Administrator, NECAT
>630.252.0689
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 12:28:22 -0500
>From: Jacob Keller <[log in to unmask]>
>Subject: Crystallography Near Venice/Padova Italy
>
>Dear Crystallographers,
>
>is anyone here aware of structural biology or otherwise
>crystallography-intensive labs around the Venice/Padova region?
>
>Thanks,
>
>Jacob Keller
>
>*******************************************
>Jacob Pearson Keller
>Northwestern University
>Medical Scientist Training Program
>Dallos Laboratory
>F. Searle 1-240
>2240 Campus Drive
>Evanston IL 60208
>lab: 847.491.2438
>cel: 773.608.9185
>email: [log in to unmask]
>*******************************************
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 19:56:59 +0200
>From: Frederic VELLIEUX <[log in to unmask]>
>Subject: Re: Crystallography Near Venice/Padova Italy
>
>Hi,
>
>Padova: Giuseppe Zanotti and Paola Spadon (Universita degli studi di Padova); Verona: Ugo Monaco (Universita degli studi di Verona, I think).
>
>I don't think there is any protein crystallography in Venezia. If you go further east, then there is Trieste...
>
>Fred.
>> Message du 27/04/10 19:28
>> De : "Jacob Keller"
>> A : [log in to unmask]
>> Copie à :
>> Objet : [ccp4bb] Crystallography Near Venice/Padova Italy
>>
>>
>> Dear Crystallographers,
>>
>> is anyone here aware of structural biology or otherwise
>> crystallography-intensive labs around the Venice/Padova region?
>>
>> Thanks,
>>
>> Jacob Keller
>>
>> *******************************************
>> Jacob Pearson Keller
>> Northwestern University
>> Medical Scientist Training Program
>> Dallos Laboratory
>> F. Searle 1-240
>> 2240 Campus Drive
>> Evanston IL 60208
>> lab: 847.491.2438
>> cel: 773.608.9185
>> email: [log in to unmask]
>> *******************************************
>>
>>
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 19:58:20 +0200
>From: Flip Hoedemaeker <[log in to unmask]>
>Subject: Re: Crystallography Near Venice/Padova Italy
>
>Dip. Scienze Chimiche and Istituto di Chimica Biomolecolare del CNR,
>sezione di Padova
>Universita di Padova
>Via Marzolo, 1
>I-35131 Padova
>
>Copied from http://www.weizmann.ac.il/esf_xtal/ which is the first place
>to look if you want to find crystallographers in Europe. I think it is
>quite up-to-date.
>
>Flip
>
>
>Jacob Keller wrote:
>> Dear Crystallographers,
>>
>> is anyone here aware of structural biology or otherwise
>> crystallography-intensive labs around the Venice/Padova region?
>>
>> Thanks,
>>
>> Jacob Keller
>>
>> *******************************************
>> Jacob Pearson Keller
>> Northwestern University
>> Medical Scientist Training Program
>> Dallos Laboratory
>> F. Searle 1-240
>> 2240 Campus Drive
>> Evanston IL 60208
>> lab: 847.491.2438
>> cel: 773.608.9185
>> email: [log in to unmask]
>> *******************************************
>>
>
>------------------------------
>
>Date: Tue, 27 Apr 2010 12:45:23 -0700
>From: James Stroud <[log in to unmask]>
>Subject: Re: Help with Bayes's theorem
>
>
>On Apr 27, 2010, at 3:08 AM, Colin Nave wrote:
>
>> Sean Eddy who is an author on the above link wrote what I regard as an
>> excellent intro to Bayesian statistics
>> ftp://selab.janelia.org/pub/publications/Eddy-ATG3/Eddy-ATG3-reprint.pdf
>
>To get the expression for E(Bob wins) (3rd equation on page 1178),
>Eddy does some "algebraic rearrangement". It's not obvious what is
>getting rearranged. Does anyone have a clue?
>
>------------------------------
>
>End of CCP4BB Digest - 26 Apr 2010 to 27 Apr 2010 (#2010-114)
>*************************************************************
|
