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MEDICAL: CONDITIONS: OBESITY:
Fatty Foods May Cause Cocaine-Like Addiction
Fatty Foods May Cause Cocaine-Like Addiction
By Sarah Klein, Health.com
March 28, 2010 2:42 p.m. EDT
CNN Health
<http://www.cnn.com/2010/HEALTH/03/28/fatty.foods.brain/>
(Health.com) -- Scientists have finally confirmed what the rest of us have
suspected for years: Bacon, cheesecake, and other delicious yet fattening
foods may be addictive.
A new study in rats suggests that high-fat, high-calorie foods affect the
brain in much the same way as cocaine and heroin. When rats consume these
foods in great enough quantities, it leads to compulsive eating habits
that resemble drug addiction, the study found.
Doing drugs such as cocaine and eating too much junk food both gradually
overload the so-called pleasure centers in the brain, according to Paul J.
Kenny, Ph.D., an associate professor of molecular therapeutics at the
Scripps Research Institute, in Jupiter, Florida. Eventually the pleasure
centers "crash," and achieving the same pleasure--or even just feeling
normal--requires increasing amounts of the drug or food, says Kenny, the
lead author of the study.
"People know intuitively that there's more to [overeating] than just
willpower," he says. "There's a system in the brain that's been turned on
or over-activated, and that's driving [overeating] at some subconscious
level."
In the study, published in the journal Nature Neuroscience, Kenny and his
co-author studied three groups of lab rats for 40 days. One of the groups
was fed regular rat food. A second was fed bacon, sausage, cheesecake,
frosting, and other fattening, high-calorie foods--but only for one hour
each day. The third group was allowed to pig out on the unhealthy foods
for up to 23 hours a day.
Not surprisingly, the rats that gorged themselves on the human food
quickly became obese. But their brains also changed. By monitoring
implanted brain electrodes, the researchers found that the rats in the
third group gradually developed a tolerance to the pleasure the food gave
them and had to eat more to experience a high.
---------------------------------------
The complete article may be read at the URL above.
Dopamine D2 receptors in addiction-like reward dysfunction and compulsive
eating in obese rats
Paul M Johnson, Paul J Kenny
Nature Neuroscience
(28 March 2010) doi:10.1038/nn.2519 Article
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