An exciting opportunity for 3 PhD studentships in statistical
bioinformatics/genetics has appeared. For details, see below.
3 PhD Scholarships in Digital Translational Genomics
Healthcare across the Disciplines aims to bring together researchers from
non-medical backgrounds to work in partnership with medical professionals and
researchers to develop solutions that will impact on patient care, lifelong
health and wellbeing. As part of this research theme, three prestigious,
University-funded, PhD scholarships are available to start October 2010 as part
of an integrated network titled Digital Translational Genomics in
Cardiovascular Disease.
Cardiovascular disease is the commonest cause of death worldwide. Recent
advances in DNA sequencing (so-called "next-generation sequencing") allow
generation of massive amounts of genetic data on patient samples. The NIHR
Cardiovascular Biomedical Research Unit (CVBRU) established in 2008 is
pioneering the use of this novel technique, coupled with other established
techniques (such as microarrays) to characterise gene expression, microRNA
expression, and genomic characteristics in patients with a range of
cardiovascular disorders. This work ultimately aims to discover novel
biomarkers for diagnosis and prognosis, and identification of novel drug
targets.
We are seeking three exceptional and highly motivated PhD students to join a
network of supervisors from backgrounds in clinical cardiology, genetics,
mathematics, engineering, statistics, computing, and bioinformatics. Each
project will be jointly supervised and be part of a vibrant network,
facilitating an integrated, multidisciplinary approach. We welcome applications
from graduates in a numerate discipline who are interested in pursuing
multidisciplinary research. Prior experience in the biological sciences is not
essential but students must have a willingness to acquire a good grounding in
biomedical science and genetics.
Award details
The scholarships cover the cost of Home/EU tuition fees and provides an annual,
tax-free maintenance stipend of £13,650. The recipient will also receive a
Research Training Support Grant of £1,000. An enhanced stipend may be available
for exceptional applicants.
Projects
The proposed PhD projects are:
Project 1: microRNA activity in Acute Coronary Syndromes: discovery of novel
functional miRs and potential new drug targets
Project 2: Identification of transcriptional biomarkers for Acute Coronary
Syndromes
Project 3: Prediction of genomic regulatory interactions and histone
modifications in Acute Coronary Syndromes, using ChIP-Seq assays
The network supervisors are;
Dr Tim Chico (Cardiovascular Science) 0114 2222396/5 [log in to unmask]
Dr Kostas Triantafyllopoulos (Mathematics and Statistics) 0114 2223741,
[log in to unmask]
Dr Marta Milo (Cardiovascular Science) 0114 222386, [log in to unmask]
Dr Chris Newman (Cardiovascular Science) 0114 271 3194,
[log in to unmask]
Dr Daniel Coca (Automatic Control & Systems Engineering) 0114 222386,
[log in to unmask]
Dr Kevin Walters (Mathematics and Statistics) 0114 222 3720,
[log in to unmask]
Applicants are advised to contact any of the above to discuss their application
in the first instance.
Eligibility
Academic requirements – applicants should have, or expect to achieve, a first or
upper second class UK honours degree or equivalent qualifications gained
outside the UK in an appropriate area of study.
Allowed study options – applicants should be registering on their first year of
study with the University for 2010/11.
Residency restrictions – awards are open to UK, EU and international
applicants.
How to apply
Applicants are advised to contact the lead supervisor to discuss their
application in the first instance.
Details of how to apply online can be found in the website:
http://www.shef.ac.uk/postgraduate/research/scholarships/projects/dtg.html
The deadline is 21 April 2010.
Kostas Triantafyllopoulos
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