Hi all,
We have recently solved a structure that is a crystallographic dimer. We
have performed UCA experiments and we observe a monomer/dimer distribution
in nearly equal proportion. This distribution does not change with protein
concentration, meaning that the two species are not in equilibrium. There
is no structural differences between the dimer and the monomer.
We would be interested in similar cases, eg coexistence of 2 multimers
without exchange between the 2 forms. Does somebody have any explanation ?
Thank you
cheers
claudine
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Pr Claudine MAYER
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Université Paris Diderot - Paris 7
Dynamique structurale des Macromolécules
Département de Biologie Structurale et Chimie
Institut Pasteur
25 rue du Dr Roux
75 015 PARIS
Tel. 01 45 68 83 87
Mobil. 06 07 23 51 16
Fax. 01 45 68 89 93
Mail. [log in to unmask]
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