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The MRC Network of Hubs for Trials Methodology Research (HTMR) is pleased to invite you to a workshop on "Using Existing Data to Inform Clinical Trial Design".
This free workshop will be held on Tuesday, March 16, 2010 from 10:00-16:30 at Goodenough College, William Goodenough Large Common Room, Mecklenburgh Square, London, WC1N 2AB.
Tea, coffee, and lunch will be provided.
Workshop Abstract: The design of a clinical trial is important to ensure the validity of the trial results. This workshop explores the ways in which existing data can be used to plan new clinical trials. Each trial phase can be informative for the next phase and other useful data includes animal models (pre-clinical trials), prior meta-analysis, and routine health record systems (hospital, registry, or primary care databases). Existing data can be manipulated using value of information analysis and Bayesian methods to help prioritise and design trials. This workshop will examine the current knowledge base, identify areas for further research, and explore opportunities and barriers for using existing data to inform trial design. The workshop agenda is below.
To register, please email the Network Coordinator at [log in to unmask]<mailto:[log in to unmask]> by close of business March 8, 2010. In your email, please state:
Name
Job Title
Organisation
Address
Email
Special dietary requirements
Special access requirements
For directions to the venue, follow this link: http://www.londonhouse.org.uk/buildings
Agenda
10:00 - 10:20
REGISTRATION
10:20 - 10.30
Introduction - overview of issues and aims and outputs of workshop
Prof. Max Parmar
(London HTMR)
10:30 - 11:10
Using pre-clinical animal studies to inform trial design
Prof. Gordon Murray (Edinburgh HTMR)
11:10 - 11:50
Phase I / II combination designs
Prof. John Whitehead
(North-West HTMR)
11:50- 12:20
COFFEE/TEA
12:20 - 13:00
Using Bayesian analysis of randomised phase II trials to plan phase III
Prof. Lucinda Billingham
(Midland Hub)
13:00 - 14:00
LUNCH
14:00 - 14:40
Prior meta-analysis, trial sample size and cumulative meta-analysis
Prof. Julian Higgins (Cambridge HTMR)
14:40 - 15:20
Using routine health record systems to inform trial design
To be confirmed
15:20 - 15:50
TEA/COFFEE
15:50 - 16:30
Value of Information Analysis in the prioritisation and design of randomised clinical trials
Prof. Nicky Welton
(ConDuCT HTMR)
16:30
CLOSE
Emily Crowe, Ph.D.
Network Coordinator
MRC Network of Hubs for Trials Methodology Research
MRC Clinical Trials Unit
Stephenson House
158-160 North Gower Street
London
NW1 2ND
Telephone: 0207 670 4901
Email: [log in to unmask]<mailto:[log in to unmask]>
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