> Bias is defined as 'difference from expectation', so the isotropic
model
> is almost certainly biased, as reflected in the higher-than-expected
> Rwork & Rfree.
Phil, sorry in my rush to go home I explained that badly: bias is
defined as 'difference between the expected and true values'. In this
case the expectation is the Rfree (or other statistic) that you would
expect to get based on the isotropic model, and we're assuming that the
optimally parameterised ADP model (whatever it is) is the one closest to
the truth: this may of course be a rash assumption since even the
optimal parameterisation may well not explain all the errors in the
model. The bias in Rfree for the isotropic model is the difference
between these.
Cheers
-- Ian
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