Meeting Title: Dissemination of medical research: avoiding and handling
publication bias
Date: 24th September 2009
Time: 2.30
Venue: RSS, London
Meeting organized by RSS Medical Section
Meeting organizer: John Davies, Jonathan Sterne
Contact details: [log in to unmask],
Stephen Pyke
Reporting of industry trials: JAMA, its impact, and the way forward
In 2005 an Editorial in the Journal of the American Medical Association
(JAMA) made clear that, so great was their concern about misleading
reporting of industry-sponsored trials, henceforth no paper would be
published that was not also guaranteed by independent statistical analysis.
In this presentation, some of the precursors to JAMA's decision will be
discussed, as well as its immediate and lasting effects for statisticians,
for the manner in which statistical analysis is carried out, and for the
pharmaceutical industry more generally.
Stephen Pyke is Global Head of Research Statistics at Pfizer.
Alex Sutton
Recent Developments in dealing with publication bias, including applications
in treatment for depression
This presentation assesses the performance of novel contour enhanced funnel
plots and a regression based adjustment method to detect and adjust for
publication biases, using a dataset of placebo controlled trials of
antidepressants previously submitted to the US Food and Drug Administration
(FDA) and matching journal publications.
Alex Sutton is Professor of Medical Statistics at the University of
Leicester.
|