Open Position :: Postdoc in computational biology

The genetics lab of Prof. Sir Bruce Ponder and the computational biology lab
of Dr. Florian Markowetz at the Cancer Research UK Cambridge Research
Institute offer a joint position for a postdoctoral researcher interested in
statistical and computational approaches to systems genetics in cancer.

The recent whole-genome scan for breast cancer [1] has identified five novel
susceptibility loci. In follow-up work the strongest locus has been narrowed
down to two SNPs in the intronic region of the FGFR2 gene [2]. However, a
detailed understanding of the disease mechanism is still missing. This
project will use a systems biology approach to elucidate the functional
roles of FGFR2 and other cancer susceptibility genes. We will integrate
diverse genomic data sources (including gene expression, SNPs, copy number
variants and others) using statistical network methods [3]. The resulting
networks will be used to identify key drivers of disease and their
functional mechanisms. The methods developed in breast cancer will also be
applied to other cancer types, e.g. lung cancer.

The position bridges between an experimental and a computational lab and is
ideal if you are interested in data analysis and method development
motivated by close collaborations with experimentalists.

The ideal applicant has a strong background in data analysis and statistical
modelling (including knowledge of R or Matlab). Experience in medical or
biological research is desireable.

If you are highly motivated to work in an interdisciplinary and very
collaborative environment at an internationally recognized research
institute, apply by sending your CV to Florian Markowetz at
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For more information please visit http://www.markowetzlab.org

References

   1. DF Easton, ..., BAJ Ponder Nature 2007. PMID 17529967
   2. KB Meyer, ... , BAJ Ponder PLoS Biology 2008. PMID 18462018
   3. F Markowetz and R Spang, BMC Bioinf, 2007. PMID 17903286

________________________________________________________________

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Florian Markowetz

Cancer Research UK
Cambridge Research Institute
Li Ka Shing Centre
Robinson Way, Cambridge, CB2 0RE, UK

phone: +44 (0) 1223 40 4315
email: [log in to unmask]
web : http://www.markowetzlab.org
skype: florian.markowetz



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ICG Campbell, Engineering Mathematics
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