Dear Brittany,
> How would an enlarged lateral ventricle affect TBSS results? Should
> these
> subjects be included in the analysis? Thanks,
this will depend crucially on just how enlarged they are. Mine are
e.g. rather large, but no worse than that I would happily include my
brain in a TBSS study. If on the other hand we are talking about one
of those scans where ~1/3 of the brain consists of ventricles, then
the registration step will have problems coping with that.
In general all "morphometric" techniques (e.g. TBSS or VBM) are useful
primarily for detecting reasonably subtle changes where we need the
whole machinery of registration, statistics etc in order to deduce if/
where there are any differences between groups. If the brains are such
that one (the lay person, like I) almost wonders how someone can still
be alive with half the brain shriveled away these techniques will
suffer. But perhaps more importantly, why would one want to use them
if the pathology is blatantly obvious from a single glance?
Good Luck Jesper
|