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SPM  April 2009

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Subject:

Re: Dartel Normalization of fMRI data

From:

John Ashburner <[log in to unmask]>

Reply-To:

John Ashburner <[log in to unmask]>

Date:

Wed, 1 Apr 2009 20:04:47 +0000

Content-Type:

text/plain

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text/plain (137 lines)

If you have the imported GM and WM (rc1 and rc2) files, then you would run 
DARTEL using these.  If I remember correctly the "import_for_dartel.m 
function was to take c1 and c2 images, and do the necessary tweaks to obtain 
the rc1 and rc2 images that DARTEL can work with.  You would not apply it to 
the fMRI data.

Best regards,
-John

On Wednesday 01 April 2009 19:19, Amir Tahmasebi wrote:
> Hi John,
>
> I used the "import_for_dartel.m" file from another posting dated on Wed.
> 6 Feb. 2008.
>
> Regards,
> Amir
>
> John Ashburner wrote:
> > I'm not quite sure what you mean by " use the code provided by John to
> > transfer both fMRI and structural data to DARTEL space". If this means
> > using the create DARTEL warped images, then then doing this again to the
> > contrast images (step 4) is going to move the data out of alignment.
> >
> > If you have SPM8b (soon to be SPM8), then maybe try skipping the "use the
> > code provided by John" step.  Generate the contrast images in native
> > space (without smoothing), and simply warp them using the new "Normalise
> > to MNI space" option of DARTEL.
> >
> > Best regards,
> > -John
> >
> > On Wednesday 01 April 2009 18:24, you wrote:
> >> Dear John and SPMers,
> >>
> >> I am facing a problem while performing DARTEL-based normalization of my
> >> fMRI data followed by group analysis.
> >>
> >> I followed the below routine to conduct first level and second level
> >> analysis on my fMRI data:
> >>
> >> (1) coregister fMRI and structural for each subject
> >> (2) perform DARTEL among segmented structural data
> >> (2) use the code provided by John to transfer both fMRI and structural
> >> data to DARTEL space
> >> (3) perform first-level analysis of the fMRI data --> output: con files
> >> (4) in order to perform second level analysis, I apply DARTEL parameters
> >> to warp my con files (using "create warp").
> >>
> >> The problem is at step 4: the warped con images seems not to have
> >> correct orientation. However, if I apply the same parameters to the fMRI
> >> data that are transformed to DARTEL space (from step 2), the data look
> >> OK.
> >>
> >> Is there anything that I am missing?
> >>
> >> Thank you,
> >>
> >> Regards,
> >> Amir
> >>
> >> John Ashburner wrote:
> >>> This will be straightforward in SPM8 - and it will combine the
> >>> transforms with an affine transform so that the spatially normalised
> >>> images are in MNI space, rather than the population average.  SPM8 will
> >>> be released very soon, but I think the necessary routines are already
> >>> available in the recent updates for SPM8b.
> >>>
> >>> An alternative strategy could be to spatially normalise contrast images
> >>> from a first level analysis done in native space, prior to doing the
> >>> 2nd level analysis.  This could be done one scan per subject.
> >>>
> >>> Best regards,
> >>> -John
> >>>
> >>> On Monday 30 March 2009 17:24, Amir Tahmasebi wrote:
> >>>> Dear John,
> >>>>
> >>>> I am using DARTEL to warp fMRI data. Using DARTEL's "create warped"
> >>>> tool, for every image you have to provide one flow field. Is there any
> >>>> way that I can apply one flow field to a bunch of images at once?
> >>>>
> >>>> Thank you,
> >>>>
> >>>> Regards,
> >>>> Amir
> >>>>
> >>>> John Ashburner wrote:
> >>>>> DARTEL is run as described in the user guide, but there is an extra
> >>>>> option that allows the resulting deformations to be automatically
> >>>>> combined with an additional affine transform.  The DARTEL warps
> >>>>> encode the inter-subject variability, and the affine transform warps
> >>>>> the average of the population to MNI space.
> >>>>>
> >>>>> Best regards,
> >>>>> -John
> >>>>>
> >>>>> On Tuesday 24 March 2009 17:49, Amir Tahmasebi wrote:
> >>>>>> Hi John,
> >>>>>>
> >>>>>> Thanks for your reply.
> >>>>>>
> >>>>>> Does this mean that the fMRI data are only affinely registered
> >>>>>> between subjects?
> >>>>>>
> >>>>>> Regards,
> >>>>>> Amir
> >>>>>>
> >>>>>> John Ashburner wrote:
> >>>>>>> If you have SPM8b (latest updates), then you should find this much
> >>>>>>> easier, as there is now an option to spatially normalise (and
> >>>>>>> spatially blur) fMRI to MNI space (as it incorporates an additional
> >>>>>>> affine mapping between DARTEL template and MNI template).  I
> >>>>>>> haven't had a chance to update the user guide for DARTEL yet, but
> >>>>>>> it should be reasonably straightforward to use.
> >>>>>>>
> >>>>>>> I expect that the t stats should be increased, and look forward to
> >>>>>>> any feedback on whether this is the case.
> >>>>>>>
> >>>>>>> Best regards,
> >>>>>>> -John
> >>>>>>>
> >>>>>>> On Tuesday 24 March 2009 16:22, Amir Tahmasebi wrote:
> >>>>>>>> Dear John and SPMers,
> >>>>>>>>
> >>>>>>>> I am trying to use DARTEL for normalization of fMRI data. I have
> >>>>>>>> looked at "how to use DARTEL for normalizing fMRI con maps?"
> >>>>>>>> thread but it is not exactly what I was looking for.
> >>>>>>>>
> >>>>>>>> I was wondering how should I use the outputs of DARTEL
> >>>>>>>> ("u_rc1*.nii" and "Template_6.nii") to normalize my fMRI data
> >>>>>>>> which is already coregistered to the corresponding structural
> >>>>>>>> data.
> >>>>>>>>
> >>>>>>>> Thank you,
> >>>>>>>> Amir

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