Based on processing rhesus macaque data (.5mm isotropic voxels for the
priors and actual data), I would suggest the following:
(1) non-linear registration will be better than linear
(2) the smoothing kernel should be significantly smaller (2-4mm)
(3) 1mm isotropic voxels are 1/8 the size of 2mm isotropic voxels, so
that will effect the ability to perform FDR corrections or FWE
corrections at the voxel level.
(4) A large sample will be needed, in a pilot analyses we computed
that you need ~50 individuals to accomplish FDR correction on voxels
that were significant <.001 uncorrected.
On Wed, Apr 15, 2009 at 4:34 PM, Matt Glasser <[log in to unmask]> wrote:
> Hi, I am helping a colleague with his non-human primate VBM analysis:
>
>
>
> He has a chimpanzee T1 scans at 0.8mm isotropic resolution and a chimp
> template of 1.6mm resolution and tissue priors at 1.6mm (to be like 1mm
> human scans and 2mm human template that is used) and we are wondering how
> the reduction in resolution and brain size will affect the analysis. I am
> wondering how the parameters in the GM_2_MNI152GM_2mm.cnf config file should
> be modified so that the VBM analysis is optimized for 0.8 mm chimpanzee
> brains with a 1.6mm chimpanzee template.
>
>
>
> Also, are there any other settings, such as smoothing kernels of the VBM
> that would be affected?
>
>
>
> Thanks,
>
>
>
> Matt.
--
Best Regards, Donald McLaren
=====================
D.G. McLaren
University of Wisconsin - Madison
Neuroscience Training Program
Office: (608) 265-9672
Lab: (608) 256-1901 ext 12914
=====================
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