Hi Frank,
such interactions are certainly possible, in particular if additional
H-bonding side chains are available to stabilize the arrangement. I'm not
aware of any examples involving main chain carbonyls, but for a discussion
of carbonyl-carbonyl side chain interactions see the following paper:
Flocco, M.M. and Mowbray, S.L. (1995) Strange Bedfellows: Interactions
between Acidic Side-Chains in Proteins, J. Mol. Biol. 254 96-105
Best wishes, Sebastiaan Werten.
----- Original Message -----
From: Frank Lee
To: [log in to unmask]
Sent: Saturday, April 25, 2009 7:47 AM
Subject: [ccp4bb] hydrogen bond between aspartate side chain and main
chain carbonyl group?
Hi,
In a new structure we observed a hydrogen bond between an aspartate side
chain and a main chain carbonyl group. Because both of them are
electronegative, I am puzzled.
My questions are: does this hydrogen bond make sense at all? any precedent
for such a hydrogen bond?
I would appreciate your help very much!
Frank
|