Hi,
Not my structure, but noticed similar bond in glycerol dehydratase,
when comparing structures. PMID: 16414072
pdb 1R9E and resid 506. (resolution 2.4 Å)
Buried rather hydrophobic environment and Asp make H-bonds to serine
hydroxyl and carbonyl.
~L~
______________________________________________________
Lari Lehtiö
Pharmacy, Department of Biochemistry and Pharmacy
Åbo Akademi University,
BioCity, FIN-20520 Turku
Finland
+358 2 215 4270
______________________________________________________
Quoting [log in to unmask]:
> Hi Frank,
>
> such interactions are certainly possible, in particular if additional
> H-bonding side chains are available to stabilize the arrangement. I'm not
> aware of any examples involving main chain carbonyls, but for a discussion
> of carbonyl-carbonyl side chain interactions see the following paper:
>
> Flocco, M.M. and Mowbray, S.L. (1995) Strange Bedfellows: Interactions
> between Acidic Side-Chains in Proteins, J. Mol. Biol. 254 96-105
>
> Best wishes, Sebastiaan Werten.
>
>
>
> ----- Original Message -----
> From: Frank Lee
> To: [log in to unmask]
> Sent: Saturday, April 25, 2009 7:47 AM
> Subject: [ccp4bb] hydrogen bond between aspartate side chain and main
> chain carbonyl group?
>
> Hi,
>
> In a new structure we observed a hydrogen bond between an aspartate side
> chain and a main chain carbonyl group. Because both of them are
> electronegative, I am puzzled.
>
> My questions are: does this hydrogen bond make sense at all? any precedent
> for such a hydrogen bond?
>
> I would appreciate your help very much!
> Frank
>
>
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