Hi all,
I am trying to normalize T2 FLAIR images of patients with brain lesions.
First, I set the origin (AC) of the images on SPM5¡¯s display command.
Then, I ran SPM5¡¯s unified segmentation process to get normalization
parameter file. I used the default setting except for the warping regularization
value, which was set to 30 because the normalized images were severely
distorted when I set the value 1.
I normalized the images with the parameter file obtained from the
segmentation process, with default setting only changing bounding boxes to
show entire brains. After normalization, some of the images were very tilted
and out of correct origins. So I corrected the tilts and set the origins again on
SPM¡¯s display command, and reoriented and resized the images.
But still, normalized images don¡¯t seem to be normalized into the same
stereotaxic space, because they show different locations on the same slice
number. I¡¯ve also tried standard SPM5 normalization process with lesion
masking, but it also led to the same result.
Attached files are same slices of the normalized images of different subjects.
Was there something that I did wrong?
What do you suggest I do? Please help me.
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