The Statistics Department at the NHMRC Clinical Trials Centre
(University of Sydney) is proud to present an upcoming course delving
into the complicated world of time-to-event analysis.
A Practical Course in Time To Event Analysis is an intensive course
aimed at biostatisticians.
The course introduces participants to the theoretical and practical
issues facing researchers who deal with time-to-event data on a regular
basis and who wish to use advanced statistical techniques to answer
complicated clinical questions.
Who should attend?
The course is ideally suited biostatisticians working in clinical and
health research areas. Ideally, participants should be familiar with
time-to-event data, have a basic understanding of proportional hazards
modelling and be comfortable to be immersed in more complex theories.
Clinicians with a strong understanding of time-to-event concepts may
also find this course of value.
Due to the practical nature of this course, only a limited number of
people will be able to register for the course.
Course emphasis
The course is designed to discuss both theory and application of simple
and complex time-to-event analysis strategies. There is emphasis on the
practical experience of performing analyses with discussion about
advantages and pitfalls for different approaches and the interpretation
of results. The course will be presented at an intermediate/advanced
level.
Proposed Topics
1. Displays:
Kaplan-Meier
Cumulative incidence
Displays of time-to-event graphs
2. Summary data
Median
Percentages at different time points
SE's of estimates
Confidence intervals
3. Comparisons of several time-to-event curves
Logrank
Stratified logrank
Tests for trend
4. Effect of heavy censoring and non-proportional hazards
Peto-prentice test
5. Proportional Hazards (PH) models
Cox model
Risk score development
Residuals for testing GOF
Residuals for testing PH assumption
Model diagnostics - collinearity
Clustered PH models
Cross-over studies involving time-to event outcomes
6. Stratified PH models
7. Time-dependent PH regression
External td covariates
Internal td covariates
Use of the offset to incorporate external information
Extended Cox model
Landmark analyses
8. Design issues in time-to-event analysis
Sample-size and power calculations
Number of events, effect size and study duration
Follow-up and accrual time considerations
Non-compliance
9. Recurrent events
Anderson-Gill model
Marginal Model (Wei, Lin & Weissfield)
Condition model (Prentice,Williams & Peterson)
Conditional model - gap between recurrent events
10. Competing risks
Cumulative Incidence curves (CIC)
Comparison of two or more CIC's [Gray]
Conditional probability curves (CPC)
Comparison of two CPC's [Pepe Mori]
Regression models
Lunn-McNeil cause specific hazards
Fine and Gray cumulative incidence
11. Other topics in time-to-event data
Censored linear regression
Left truncated data
Censoring types
Dates
Full Course (5 days) : Monday, 22nd - Friday 26th September 2008
Intermediate component (3 Days)
Monday, Tuesday & Wednesday, 22nd - 24th September 2008
Advanced component (3 days)
Wednesday, Thursday & Friday, 24th - 26th September 2008
Note: The advanced course starts on Day 3 of the 5 day course. Wednesday
24th September is included in both components of the course.
Course fees ($AUD, includes GST)
Days 1-5
Full
Days 1-3 Intermediate
Days 3-5 Advanced
Standard rate
$2,500
$1,850
$1,850
* Confirmation of registration (with receipt) will only occur with
full payment.
Venue
The course will be held at the Citigate Central Sydney Hotel, 169-179
Thomas Street, Haymarket. This is ideally located in Sydney's CBD, with
ready access to public transport & accommodation. Excellent restaurants
and cafes are located at nearby Chinatown and Darling Harbour.
Laptops
Participants should bring their own laptop. User-friendly software
will be provided as part of the course.
Note : If participants are unable to provide their own laptop, please
contact us and we will try to make alternative arrangements.
Further Information
Tel: +61 2 9562 5000 and ask for Kew Flood
E-mail: [log in to unmask]
A/Professor Val Gebski
Director, Biostatistics and Research Methodology
NHMRC Clinical Trials Centre University of Sydney,
Camperdown NSW 1450 Australia
Ph: 61-2-9562 5000
Fax 61-2-9565-1863
Mob: 0412 309 967
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