Hello,
I have several dozen T1-weighted MRI scans from subjects with focal lesions.
I wish to do VBM analysis on these. One problem is that sometimes tissue
that is within the lesion variably gets classified as GM or WM. To deal
with this, I would like to turn all voxels within the lesion to a zero (by
masking with a binary mask). When I try this, I see that absolutely no
voxels within the lesion are classified as GM or WM, instead they are
ignored when they are zeros; furthermore, the non-lesion GM and WM appear to
be properly classified with this mask approach.
This seems fair and sensible but I have not seen this done before in prior
reports of VBM in subjects with a brain lesion. Are there any caveats or
suggestions regarding this approach?
Thanks,
Sarvy
|