Dear SPMers,
I have a couple of questions regarding the normalisation step in SPM5 using the Unified Segmentation procedure:
- Is the procedure to (1) Co-Register EPI and anatomical T1 of the subject, (2) Normalise the T1 of the subject with a template delivered with SPM (T1.mnc?) (3) To apply the parameters derived from this normalisation to the EPIs. Is that correct or am I missing something?
- How does the Unified Segmentation approach compare to standard normalisation in particular in patients with mostly subcortical (but sometimes also cortcial) lesions (mostly due to stroke)
- If the normalisation results in bad results due to the presence of the lesion, is it possible to mask out areas which shouldn't be considered for normalisation?
- Finally, could one use Unified Segmentation normalisation in some patients and "classical" normalisation in other patients and then use them all in one statistical analysis? (i.e., mix both methods in one sample)
Thanks a lot in advance &
Kind Regards,
Andre
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