Dear colleagues
We would like to bring to your attention the following Marie Curie PhD
studentship to work on the application of single molecule spectroscopy to
the DNA damage response.
The project is funded by the Marie Curie initial training network; Imaging
the DNA Damage Response, under the supervision of Dr Mark Osborne
(Chemistry) and Prof. Tony Carr (Genome Damage and Stability Centre).
We are seeking to appoint a PhD student for 3 years starting in October 2008
(or soon after) to develop single molecule techniques for detecting and
imaging the DNA damage response (DDR). Understanding the mechanism by which
the cell maintains genome stability under stress is not only key to
providing new insights into cell mutation and carcinogenesis, but also the
development of tailored therapies and medical interventions at the molecular
level.
The University of Sussex UK led project aims to image DDR at the level of
single DNA and chromatin fibres in order to directly visualise the proteins
associated with sites of damage and stalled replication forks. As part of an
EU wide initial training network (ITN), the project provides an opportunity
for the successful candidate to engage in highly multidisciplinary research
using state-of-the-art laser microscopy, molecular immobilisation and
protein tagging techniques.
EU candidates (not UK) with a strong interest in the application of physics,
optics and laser spectroscopy in the biosciences can seek further details
from Dr. Mark Osborne ([log in to unmask] ) or Prof. Tony Carr
([log in to unmask]).
Dr Mark Osborne
Department of Chemistry and Biochemistry
School of Life Sciences
University of Sussex
Falmer
Brighton
Email: [log in to unmask]
Tel: 01273 678328
http://www.sussex.ac.uk/chemistry/profile41910.html
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