Hi all
I am looking for fMRI expert opinions on the following situation:
We have data from an intervention study over two time points. The aim of the
study was to compare changes in activations during a cognitive task over
time between the treatment and the control group.
Unfortunately, the two groups are not equal at baseline. Although allocation
to groups was random, the intervention group happens to show much
stronger/more activations at baseline. This makes it obviously hard to
attribute the changes in activation over time to the treatment rather than
the baseline activation.
I am wondering if there is a good way to statistically control for baseline
activation when looking at the change over time or whether we should accept
the situation as it is and not proceed any further with this data.
Any opinions are much appreciated!
Thanks
Anna
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