Hi Bernhard,
Google books is your friend...
It returns 2 hits for
"Although the hydrogen bond is not strong it has great significance in
determining the properties of substances. Because of its small bond energy"
Both are essays / chapters by Max Perutz
I Wish I'd Made You Angry Earlier: Essays on Science, Scientists, and Humanity - Page 166
has the quote attributed to Pauling but without reference.
http://books.google.com/books?id=GkODMkCWndQC&pg=PA166&dq=%22Although+the+hydrogen+bond+is+not+strong+it+has+great+significance+in+determining+the+properties+of+substances.+Because+of+its+small+bond+energy%22&sig=ACfU3U0HC6n1toHJgD9Z-bedRSs7eVvz8Q
And
Pioneering Ideas for the Physical and Chemical Sciences: Josef Loschmidt's ... - Page 1
by W. Fleischhacker, Thomas Schönfeld
has a chapter titled "The significance of the hydrogen bond for physiology" by Max Perutz
where the quote is attributed to being from Pauling's "newly published Nature of the Chemical Bond"
which Perutz obtained with a Christmas 1939 "book token" so I presume it was the 1940 version.
http://books.google.com/books?id=cMc9BHNyIWsC&pg=PA1&lpg=PA1&dq=%22Although+the+hydrogen+bond+is+not+strong+it+has+great+significance+in+determining+the+properties+of+substances.+Because+of+its+small+bond+energy%22&source=web&ots=sU9k_3dU9w&sig=3ZCCE8u8ZpLBa-ycU2v0eT1s4og&hl=en&sa=X&oi=book_result&resnum=2&ct=result
The 1960 version of Pauling's book is on Google books and it has a similar but not identical statement.
see pp. 449-450.
http://books.google.com/books?id=L-1K9HmKmUUC&printsec=titlepage&dq=Nature+of+the+Chemical+Bond+Pauling&source=gbs_toc_s&cad=1#PPA449,M1
Regards,
Mitch
-----Original Message-----
From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Bernhard Rupp
Sent: Wednesday, July 23, 2008 10:26 PM
To: [log in to unmask]
Subject: [ccp4bb] quote source
Dear All,
does someone know the proper reference of this L. Pauling statement?
"Although the hydrogen bond is not strong it has great significance in
determining the properties of substances. Because of its small bond energy
and the small activation energy involved in its formation and rupture, the
hydrogen bond is especially suited to play a part in reactions occurring at
normal temperatures. It has been recognised that hydrogen bonds restrain
protein molecules to their native configurations, and I believe that as the
methods of structural chemistry are further applied to physiological
problems it will be found that the significance of the hydrogen bond for
physiology is greater than that of any other single structural feature".
It is quoted by Perutz but no ref
Thx, br
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