Dear Jacob,
We have been working on this for an year or so. We have a paper partially in the review process. Unfortunately, the referees were not very excited about the idea. However, we are developing some automation to speed up the time consuming process of placing the drops on the loops.
This method seems to have some advantges and some issues in using the known crystallization conditions. This could also give trouble with solutions containing volatile compounds.
Kind regards,
Mathews
-----Original Message-----
From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Jacob Keller
Sent: Tuesday, June 03, 2008 1:14 PM
To: [log in to unmask]
Subject: [ccp4bb] Crystals grown directly on loop?
Dear crystallographers,
Has anyone ever tried to grow crystals directly on some kind of mountable support, such as some kind of loop or film, which could be frozen directly?
I understand that there are some microfluidic plates through which the crystals can be diffraction-screened, but what about for more conventional, known crystallization conditions? It seems that this would be a spectacular way to decrease damages/stresses caused by handling...
Jacob Keller
*******************************************
Jacob Pearson Keller
Northwestern University
Medical Scientist Training Program
Dallos Laboratory
F. Searle 1-240
2240 Campus Drive
Evanston IL 60208
lab: 847.491.2438
cel: 773.608.9185
email: [log in to unmask]
*******************************************
|