Have you checked out the chapter that Rik Henson wrote on this subject
(attached). I think you'll find some useful information in there.
It's a draft and it's from 2006. Maybe there is a newer version of this
chapter around?
Cheers,
Jan
Zhang Zhiqiang wrote:
> Mclaren,
>
> Thank you very much for you reply! But can I use the "2-sample t-test"
> in the SPM(basic model) to compare the z-map of one patient to that of
> controls?
>
> Thanks again,
>
> Zhiqiang Zhang
>
> */"MCLAREN, Donald" <[log in to unmask]>/* 写道:
>
> Its not a 2 sample T-test. The best solution is to compute the Z-score
> of the patient using the mean and standard deviation of the control
> group.
>
> On Thu, May 8, 2008 at 9:19 AM, Zhang Zhiqiang wrote:
> > Dear SPMers,
> >
> > It's known that for some disease, for examle the focal epilepsy, each
> > patient has a singular feature, and need to be studied
> individually. Now I
> > want to look into the BOLD changes in each patient comparied to normal
> > controls. then, I'd like to know whether it is feasible to perform a
> > 2-sample t-test to compare 1 patient to a group of controls (20 normal
> > subjects, i.e.).
> >
> > It's seems that this "1 vs n" comparsion is prevalent in PET study
> using
> > SPM, I
> > don't know whether it is still OK in fMRI study. Has anyone
> carried it out?
> > and
> > are there some document on this issue for recommedation? Thank you
> very
> > much!
> >
> > Any reply will be very appreciated!
> >
> > Best,
> >
> > Zhiqiang Zhang
> > Dept. of Med. Img.
> > Jinling Hospital
> > Nanjing University, China.
> >
> > ________________________________
> > 雅虎邮箱,您的终生邮箱!
>
>
>
> --
> Best Regards, Donald McLaren
> =====================
> D.G. McLaren
> University of Wisconsin - Madison
> Neuroscience Training Program
> Tel: (773) 406 2464
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