Hello,
as these two samples come from different populations and do NOT represent a
repeated measure in the same subjects,
a two-sample t-test (or ANCOVA, if covariates are involved) should be the
correct procedure.
To my opinion, a paired t-test is not appropriate, even if cases are
"case-by-case" matched for age and gender,
as the measurements stem from different subjects.
br,
Philipp
Max Planck Institute of Psychiatry
NMR Research Group
Kraepelinstr. 2-10
80804 Munich
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Phone: 0049-89-30622-413
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