Hi Jason,
RosettaDesign server will do just that:
http://rosettadesign.med.unc.edu/
You can specify that certain residues remain unchanged (say active site),
that they fall into defined physico-chemical categories (polar, hyrophobic,
etc), or let the server change all residues into whatever is compatible
with your original structure.
If you want a stand-alone version of Rosetta:
http://depts.washington.edu/ventures/UW_Technology/Express_Licenses/Rosetta/
At 06:45 AM 4/2/2008, Jason Greenwald wrote:
>I am looking for software or a server to run the 3D-1D profile search
>in reverse: that is I have a new structure (not in yet deposited in
>PDB) and I want to see what sequences might fit well to this 3D
>structure.
>Can someone point me in the right direction?
>
>-jason
=========================================================================
| Mensur Dlakic, PhD | Tel: (406) 994-6576 |
| Department of Microbiology | Fax: (406) 994-4926 |
| Montana State University | Lab: (406) 994-6237 |
| 109 Lewis Hall, P.O. Box 173520 | http://myprofile.cos.com/mensur |
| Bozeman, MT 59717-3520 | E-mail: [log in to unmask] |
=========================================================================
|