Reply-To: | | [log in to unmask][log in to unmask], 15 Apr 2008 10:08:12 -0500583_us-ascii Hi, I cannot tell you how to make density better. However, you can verify if the substrate is in by anomalous signal if you can replace an atom in you substrate, or add one to it with the absorption edge in synchrotron-tunable energy range. In any case, you should keep in mind that depending on you compound and its binding nature to the protein, it may be sitting in many orientations and in many conformations. If this is true, it will be next to impossible to see all of it even at much higher resolutions than yours. Good luck, N. [...]41_15Apr200810:08:[log in to unmask] |