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Postdoctoral fellow (fulltime)
Leiden University, Leiden, The Netherlands
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Job description
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TOP Institute Pharma (TI Pharma) has granted our proposal to set up a
mechanism-based PK-PD modelllng platform. This platform focuses on the
transfer of knowledge from academia to the pharmaceutical industry and
is a collaborative effort of four academic partners and six industrial
partners. Unique to this platform is the availability of shared
databases on disease and drug related parameters.
The aim of the platform is to provide a scientific basis for rational
drug discovery and development with a strong focus on priority
medicines. Challenges are 1) to develop mechanism-based PKPD models to
characterise disease progression and to predict the effects of ageing on
clinical response and 2) to create a translational research framework
that allows extrapolation of preclinical to clinical and epidemiological
findings. Existing (pre-) clinical data will be analysed with advanced
data analysis software tools such as NONMEM and R.
The disease progression working group will consist of two PhD students
and two post-doctoral research fellows. At present, we are looking for a
highly motivated scientist (PhD degree) to investigate disease models in
COPD. This appointment will be for 4 years.
Requirements
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The post-doctoral fellow should have the following background and
competencies:
* A strong background in modelling & simulation
* A degree in Biostatistics, Medicine, Bioengineering,
Biopharmaceutical Sciences, Physiology or equivalent scientific training
* Conceptual thinker
* Problem-solving and coaching skills are essential
* Ambitious
* Creative
* Interested to perform research in a unique multidisciplinary
setting
Organisation
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The Leiden Division of Pharmacology at the Leiden/Amsterdam Center for
Drug Research (LACDR) has a long-standing expertise in the development
of Pharmacokinetic/Pharmacodynamic (PKPD) models to predict efficacy and
safety of drugs. Given the nature of disease, the COPD project is a
challenging subject which requires understanding of statistical
methodology (principal component analysis, multivariate analysis,
longitudinal and hierarchical models). Knowledge of Bayesian concepts
is highly desirable.
Conditions of employment
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The employment for this position will be full time for 4 years.
Additional conditions of employment:
You will work as a team member of a TI Pharma project. The project team
comprises academic and industrial partners. In this case, the partners
are: universities of Leiden and Groningen, the University Medical Center
of Utrecht, the Erasmus Medical Center and the companies Eli Lilly,
Johnson & Johnson, GSK, Nycomed, Organon and Pfizer. You will attend a
unique drug discovery education and training program offered by TI
Pharma.
Additional Information
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For instance:
Additional information can be obtained through one of the following
links:
http://www.lacdr.nl
Application
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You can apply by sending your application to:
Contact person
Dr. O. Della Pasqua
Division of Pharmacology, Leiden/Amsterdam Center for Drug Research
Leiden, The Netherlands
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+44 7876031907
Margot Beukers, PhD
Project Manager
TI Pharma PK PD Modeling Platform
Availability (CET):
Monday: 12.30 - 16.30
Wednesday: 07.30 -16.30
Thursday: 07.30 -11.30
Friday: 12.30 - 16.30
Gorlaeus Laboratories, HB811, Leiden University
Einsteinweg 55
2333 CC, Leiden, The Netherlands
Email: beukerspkpd AT lacdr DOT leidenuniv DOT nl
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Tel: +31-71-5276276
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