POSTDOCTORAL POSITION AVAILABLE
The Structure and Function of Membrane Biology Laboratory (SFMB) is
focused on understanding how membrane proteins work, using a
combination of structural and functional approaches. The SFMB is
affiliated with the Université Libre de Bruxelles and is located in
Brussels, Belgium.
A main focus of the lab is the study of multidrug transporters
responsible for chemoresistance in cancer therapy or antibiotic
treatments. In collaboration with four other laboratories, we are
starting a project aiming at deciphering the structure of ATP-binding
cassette transporters and secondary transporters, and will develop new
diagnostic tools and therapeutic approaches. An array of highly
specific recombinant antibodies will be generated against the targets
(including, among others, P-gp and MRP1). These reagents will be
used, on one hand, as putative diagnostic and/or therapeutic tools
against multidrug resistance and, in parallel, as crystallization aids
in an effort to obtain high-resolution structure of the targets.
A three years postdoctoral position is available as of June 1st 2008
to study the structure and function of a set of key ABC transporters
involved in resistance to chemotherapy. The postdoc will be in charge
of production and purification of the targets from existing strains,
characterize the diagnostic and therapeutic potential of the
antibodies and take part in the crystallization effort. The work will
be geared both towards a better understanding of the function of the
transporters (basic science) and the development of diagnostic and
therapeutic tools (applied science).
Candidates should have a recent PhD and have a strong background in
structural biology, protein expression and purification, preferably
with membrane proteins; molecular biology skills are a plus.
Candidates should not be Belgian nationals.
Applications: Send a CV, a list of publications, a short overview of
research activities and the name of two to three references to
[log in to unmask] or [log in to unmask] Preselected
applicants will be requested to travel to Brussels for a lecture and
an interview.
--
Marc F. Lensink
Centre for Structural Biology and Bioinformatics CSBB
Université Libre de Bruxelles [log in to unmask]
Boulevard du Triomphe - CP 263, B-1050 Brussels, Belgium
tel: +32 2 650 5411 secr: +32 2 650 2013 fax: +32 2 650 5425
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