Structural Studies on Human Proteins of Medical Relevance
Karolinska Institutet, Structural Genomics Consortium
Department of Medical Biochemistry and Biophysics

Web link: http://sgc.ki.se/jobs.html

Structural Biochemistry of Integral Membrane Proteins (2 positions)
We seek two talented researchers for our post-doc programs on human integral
membrane proteins
1. Membrane protein chemistry/structural biology. The applicant should have
strong background in recombinant membrane protein production in E. coli,
preferably with some experience of protein crystallisation. Main aims
include the implementation of new and improved methods for purification and
crystallisation of integral membrane proteins. Knowledge about X-ray
crystallography would be an advantage but is not a requirement.
2. Membrane protein X-ray crystallography. The applicant should have a
strong background in X-ray crystallography with a good track record. Main
tasks are crystallisation screening, crystal optimisation, data collection
and structure determination of integral membrane proteins. Previous
experience with membrane proteins would be an advantage but is not a
requirement.
Supervisor: Prof. Pär Nordlund, Starting date: No later than October 2008

Structural Biochemistry of Metabolic/Signalling Proteins (1 position)
We seek a talented researcher to join our program on human
metabolic/signalling proteins, including areas such as phosphoinositide
signalling, lipid metabolism and lipid transport. The postdoc is expected to
contribute to collaborative research on proteins from our target list, as
well as in-depth studies on a sub-set of proteins. This includes expression,
purification, characterisation, crystallisation and structure determination
of target proteins as well as functional characterisation.  Suitable
candidates have a PhD in a relevant area, preferably within Molecular
Biology, Biochemistry, Structural Biology or related subjects and a strong
publication record. A strong background within X-ray crystallography would
be and advantage.
Supervisor: Assoc. Prof. Helena Berglund, Starting date: No later than
October 2008

X-ray crystallography (1 position)
The X-ray crystallography program is dedicated towards high throughput
protein crystallisation, data collection and structure determination and
requires a strong background in X-ray crystallography. Main aims include the
implementation and application of parallel (high throughput) methods for
X-ray crystallography and structure determination of human proteins. The
Core Crystallography unit is expected to contribute senior expertise in the
structure determination process and is often exposed to the more challenging
structure determination/refinement projects.
Supervisor: Dr. Martin Moche, Starting date: No later than October 2008

All SGC research is carried out by teams in a highly collaborative manner,
and applicants must therefore have strong interpersonal skills as well as
the ability to work independently.

For a list of SGC publications, please visit:
http://www.thesgc.com/publications/

The positions are offered for 2 years, and general requirements to be
eligible to apply are a Non-Swedish citizenship and a Doctoral degree from a
University outside Sweden.

For further information, or to apply, contact Dr. Johan Weigelt, Chief
Scientist (+46 8 524 86840, [log in to unmask]). The application should
contain a short CV, an outline of primary research interests and a list of
at least two reference persons.

Applications deadline: March 16, 2008

The Structural Genomics Consortium (SGC) is a not-for-profit organization
that aims to determine the three dimensional structures of proteins of
medical relevance, and place them in the public domain without restriction.
The SGC operates out of the Universities of Oxford and Toronto and
Karolinska Institutet, Stockholm. During the first phase of the project,
more than 450 protein structures were deposited in the PDB. In its second
funding phase (July 1 2007 - June 30 2011) SGC aims to determine more than
650 novel structures, including 9 structures of human integral membrane
proteins. SGC works on a Target List of ~2,400 proteins with relevance to
human health comprising proteins associated with diabetes, cancer, genetic
and epigenetic disease as well as with infectious diseases such as malaria. 

__________________________________________________

Martin Moche, Ph.D., M.Sc.
Senior scientist
Karolinska Institutet
MBB/SGC
Scheeles väg 2
171 77 Stockholm
Sweden
Phone: +46-8-524 868 43
Mob:   +46-733-229327
Fax:   +46-8-524 868 68
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