Dear all, will highly appreciate if the ad below is brought to the
attention of students who may be interested. Thanks!
Applications are invited from recent graduates or final year
undergraduates for the following PhD project in Cambridge, UK:
Structure of bacterial respiratory complex I
The aim of the project is to determine the crystal structure of
respiratory complex I, which plays a central role in cellular energy
production and is implicated in many human neurodegenerative diseases. We
have determined the first X-ray structure of the catalytic core of this
large molecular machine (Science 311, 1430-6 and Science 309, 771-4) and
now aim to solve the structure of the entire complex by X-ray
crystallography.
This studentship will provide an excellent opportunity to gain broad
experience in structural biology, X-ray crystallography and biochemistry.
The Medical Research Council Dunn Human Nutrition Unit is a leading
international research centre that provides an opportunity for cutting-
edge research. Facilities include a range of fermentors/chromatography
systems for protein purification, electron microscopes, crystallisation
robots and home X-ray sources. We have regular access to ESRF and Diamond
synchrotrons. Our students are normally part of the Graduate School of
Biological Sciences of Cambridge University and are members of one of the
University colleges. The MRC studentship providing college fees and
stipend (about £15000 pa subject to review) will be offered on a
competitive basis subject to eligibility. The starting date is October
2008.
Enquiries should be directed to:
Dr. L.A. Sazanov ([log in to unmask])
Full details are available at http://www.mrc-dunn.cam.ac.uk/
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