Hi,
Your EV4 is just modelling the whole-group mean, which is fine.
Alternatively, you could just omit EV4 and demean the data instead
using the -D flag in randomise.
Cheers.
On 30 Nov 2007, at 14:56, Agnieszka Burzynska wrote:
>
> Hi,
>
> I have a problem with design for randomise analysis of tbss data and
> didnt find answers in the archives:
>
> -I use Glm_gui to set up the design matrix
> -First i compared patients vs controls: I had:
> (design.con)
> /ContrastName1 controls>patients
> /ContrastName2 patients>controls
> /NumWaves 2
> /NumContrasts 2
> /PPheights 1.000000e+00 1.000000e+00
> /RequiredEffect 1.501 1.501
> /Matrix
> 1.000000e+00 -1.000000e+00
> -1.000000e+00 1.000000e+00
>
> design.mat
> /NumWaves 2
> /NumPoints 35
> /PPheights 1.000000e+00 1.000000e+00
>
> /Matrix
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 1.000000e+00 0.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
> 0.000000e+00 1.000000e+00
>
> -now I want to see the interaction with age --> as far as I know
> ANOVA 2x2 design is suitable. I used the information at ...fsl/feat5/
> detail.html#higher to create the below matrix:
>
> EV1 I assume is patient (-1) and control (1)
> EV2 is sex: male (1) and female (-1)
> EV3 is the product of EV1 and EV2
> But what is EV4 here in case of FA data from tbss?
>
> I will be very grateful for all suggestions,
> (also about which other model to use for such data if ANOVA is not
> recommended for this data?)
> Best wishes,
> Aga
>
> /ContrastName1 patient/control
> /ContrastName2 sex
> /ContrastName3 patient/control x sex
> /NumWaves 4
> /NumContrasts 3
> /PPheights 2.060606e+00 2.060606e+00 2.060606e+00
> /RequiredEffect 1.574 1.574 1.574
>
> /Matrix
> 1.000000e+00 0.000000e+00 0.000000e+00 0.000000e+00
> 0.000000e+00 1.000000e+00 0.000000e+00 0.000000e+00
> 0.000000e+00 0.000000e+00 1.000000e+00 0.000000e+00
>
> /NumWaves 4
> /NumPoints 35
> /PPheights 2.000000e+00 2.000000e+00 2.000000e+00
> 1.000000e+00
>
> /Matrix
> 1.000000e+00 1.000000e+00 1.000000e+00 1.000000e+00
> 1.000000e+00 1.000000e+00 1.000000e+00 1.000000e+00
> 1.000000e+00 1.000000e+00 1.000000e+00 1.000000e+00
> 1.000000e+00 1.000000e+00 1.000000e+00 1.000000e+00
> 1.000000e+00 1.000000e+00 1.000000e+00 1.000000e+00
> 1.000000e+00 1.000000e+00 1.000000e+00 1.000000e+00
> 1.000000e+00 1.000000e+00 1.000000e+00 1.000000e+00
> 1.000000e+00 1.000000e+00 1.000000e+00 1.000000e+00
> 1.000000e+00 1.000000e+00 1.000000e+00 1.000000e+00
> 1.000000e+00 -1.000000e+00 -1.000000e+00 1.000000e+00
> 1.000000e+00 -1.000000e+00 -1.000000e+00 1.000000e+00
> 1.000000e+00 -1.000000e+00 -1.000000e+00 1.000000e+00
> 1.000000e+00 -1.000000e+00 -1.000000e+00 1.000000e+00
> 1.000000e+00 -1.000000e+00 -1.000000e+00 1.000000e+00
> 1.000000e+00 -1.000000e+00 -1.000000e+00 1.000000e+00
> 1.000000e+00 -1.000000e+00 -1.000000e+00 1.000000e+00
> 1.000000e+00 -1.000000e+00 -1.000000e+00 1.000000e+00
> 1.000000e+00 -1.000000e+00 -1.000000e+00 1.000000e+00
> -1.000000e+00 1.000000e+00 -1.000000e+00 1.000000e+00
> -1.000000e+00 1.000000e+00 -1.000000e+00 1.000000e+00
> -1.000000e+00 1.000000e+00 -1.000000e+00 1.000000e+00
> -1.000000e+00 1.000000e+00 -1.000000e+00 1.000000e+00
> -1.000000e+00 1.000000e+00 -1.000000e+00 1.000000e+00
> -1.000000e+00 1.000000e+00 -1.000000e+00 1.000000e+00
> -1.000000e+00 1.000000e+00 -1.000000e+00 1.000000e+00
> -1.000000e+00 1.000000e+00 -1.000000e+00 1.000000e+00
> -1.000000e+00 1.000000e+00 -1.000000e+00 1.000000e+00
> -1.000000e+00 -1.000000e+00 1.000000e+00 1.000000e+00
> -1.000000e+00 -1.000000e+00 1.000000e+00 1.000000e+00
> -1.000000e+00 -1.000000e+00 1.000000e+00 1.000000e+00
> -1.000000e+00 -1.000000e+00 1.000000e+00 1.000000e+00
> -1.000000e+00 -1.000000e+00 1.000000e+00 1.000000e+00
> -1.000000e+00 -1.000000e+00 1.000000e+00 1.000000e+00
> -1.000000e+00 -1.000000e+00 1.000000e+00 1.000000e+00
> -1.000000e+00 -1.000000e+00 1.000000e+00 1.000000e+00
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Stephen M. Smith, Professor of Biomedical Engineering
Associate Director, Oxford University FMRIB Centre
FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK
+44 (0) 1865 222726 (fax 222717)
[log in to unmask] http://www.fmrib.ox.ac.uk/~steve
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