Hi Doug,
I am very suprised by this and would not back down (well, it propably
depends on how much you want to have the paper in the journal ;) But
even with my very limited statistical understanding I believe that FDR
is a valuable approach to dealing with the multiple comparisons issue,
and I believe that there are numerous papers out there using this
approach (searching for fMRI and FDR in Goolge scholar yields 791 hits),
including a number of papers investigating its merits and pitfalls (as
in Marchini and Presanis, NI 2004). In my view, this should suffice to
comvince the editor that using FDR is "acceptable".
Best,
Marko
Doug Burman schrieb:
> I have an article that has been reviewed where the only major complaint
> was that the reviewer would not accept the results as valid because we
> used a FDR correction (p=0.05) -- even though our cluster sizes were
> fairly large, we also used an extent threshold of 25, and our Z-scores
> were generally greater than 5.0. The editor is backing him up, and
> refuses to publish our findings unless we satisfy him that our "result is
> not a chance finding".
>
> Many of our primary findings would survive a FWE correction if we applied
> a mask. I find it disturbing, however, that a FDR correction is not
> considered an acceptable method for multiple-comparisons correction by
> this reviewer / editor, and some highly-informative brain / behavior
> correlations in our study require this correction. Any suggestions on
> articles and explanations on the validity of the FDR approach?
>
> (I know this has been discussed on the list before, but I suspect the
> listserv discussion will not in itself satisfy the editor.)
>
> Doug Burman
>
>
--
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Marko Wilke (Dr.med./M.D.)
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Universitäts-Kinderklinik University Children's Hospital
Abt. III (Neuropädiatrie) Dept. III (Pediatric neurology)
Hoppe-Seyler-Str. 1, D - 72076 Tübingen
Tel.: (+49) 07071 29-83416 Fax: (+49) 07071 29-5473
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