I have an article that has been reviewed where the only major complaint
was that the reviewer would not accept the results as valid because we
used a FDR correction (p=0.05) -- even though our cluster sizes were
fairly large, we also used an extent threshold of 25, and our Z-scores
were generally greater than 5.0. The editor is backing him up, and
refuses to publish our findings unless we satisfy him that our "result is
not a chance finding".
Many of our primary findings would survive a FWE correction if we applied
a mask. I find it disturbing, however, that a FDR correction is not
considered an acceptable method for multiple-comparisons correction by
this reviewer / editor, and some highly-informative brain / behavior
correlations in our study require this correction. Any suggestions on
articles and explanations on the validity of the FDR approach?
(I know this has been discussed on the list before, but I suspect the
listserv discussion will not in itself satisfy the editor.)
Doug Burman
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