Warren,
Quite a beauty... what a nice way to show the effect of the
mutation in the binding site.
really nice,
Mario
Warren DeLano wrote:
>http://delsci.com/morph
>
>It's a start...
>
>-----Original Message-----
>From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of
>Gerard DVD Kleywegt
>Sent: Wednesday, October 03, 2007 6:55 AM
>To: [log in to unmask]
>Subject: Re: [ccp4bb] Morphing with mutations
>
>
>
>> What about to do a cartesian morphing with the mutated
>>
>>
>residue
>
>
>>added (or removed) atoms having initial ( or final) coordinates taken
>>
>>
>from
>
>
>>previous common atom?
>> Will work? Coloring may be a factor... but with a manual
>>
>>
>editing
>
>
>>perhaps...
>>
>>
>
>you mean, for instance, if you have an Ala->Trp you call the ala 'trp',
>add
>all missing 'trp' side-chain atoms and put them on top of the CB, and
>then
>morph to the real trp, so the additional side-chain atoms will slowly
>"explode" out of the CB and towards their final positions? (and for a
>Trp->Ala
>mutation you could do the same thing of course, but the extra side-chain
>atoms
>would then be "sucked up" by the CB like a black hole) yep, that is a
>trick
>that would probably work!
>
>if anyone gets it to work, i would be interested in seeing the result
>and
>learning details, so i could add it to the lsqman manual or the morphing
>
>tutorial
>
>--dvd
>
>******************************************************************
> Gerard J. Kleywegt
> [Research Fellow of the Royal Swedish Academy of Sciences]
>Dept. of Cell & Molecular Biology University of Uppsala
> Biomedical Centre Box 596
> SE-751 24 Uppsala SWEDEN
>
> http://xray.bmc.uu.se/gerard/ mailto:[log in to unmask]
>******************************************************************
> The opinions in this message are fictional. Any similarity
> to actual opinions, living or dead, is purely coincidental.
>******************************************************************
>
>
--
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