STRUCTURAL BIOCHEMISTRY OF THE INTERACTION OF THE NEURONAL PROTEIN TAU
WITH TUBULIN
A post-doctoral fellowship is available immediately at the Laboratoire
d'Enzymologie et Biochimie Structurales (LEBS), CNRS, Gif-sur-Yvette,
France. The contract will be initially for a period of one year.
Our group works on structural aspects of the regulation of microtubule
assembly. This project deals with Tau family proteins. These proteins
favor microtubule assembly but, when abnormally phophorylated, they
aggregate. They are associated with the symptoms of Alzheimer disease;
in addition, some familial forms of dementia are correlated with
mutations in Tau. In a joint project with an NMR group (for recent work
on the interaction of Tau with microtubules see Sillen et al. (2007)
Biochemistry 46, 3055), we will study the interaction of Tau with
tubulin by biophysical and biochemical methods in solution and
characterize by X-ray crystallography the complexes formed.
The lab has state of the art equipment for protein purification and
characterization. Crystallization robotics and X-ray diffraction
equipment are also available in-house (see
http://www.lebs.cnrs-gif.fr/home.html). We are located in a
multidisciplinary life sciences campus, 40 minutes by direct train from
the centre of Paris with a regular access to synchrotron sources
including the closeby french synchrotron SOLEIL.
Applicants should hold a Ph. D., have experience in biochemistry
(cloning, protein expression, purification and characterization) and an
interest in structural studies. Experience in protein crystallization
and crystallography would be an advantage but motivated biochemists –
molecular biologists will be trained in these techniques.
To apply, please send a CV, a short summary of your research experience
and the names and contact information of two referees by e-mail to Dr.
Marcel Knossow ([log in to unmask]). For details on the group
please see our web page
(http://www.lebs.cnrs-gif.fr/knossow/knossowang.html).
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