Dear all,

Our laboratory can undertake Academic or Commercial Project in protein  
expression, crystallization of protein/nucleic acid/complex and some  
functional study with considerable low cost (or you have to apply in  
conjunction with us for the funding of Chinese government).

We have an independent protein crystallography laboratory, managed by an  
experienced crystallographer.  Now we would like to undertake some  
projects which are thought by their providers suitable for collaboration.  
What we can do includes protein expression with E.coli, yeast or cell  
line; crystallization of protein, DNA, RNA, protein-ligand complex or  
protein-DNA/RNA complex; data collection, structure solution and  
especially some related functional study including site-directed mutation,  
enzyme activity assay, binding constant determination, etc. The satisfying  
peripheral academic environments and facilities will favor the functional  
study.

Because of our great advantage of comparatively low labor cost, we can  
provide those services with low cost; I think generally the overall cost  
of completing a common project (from protein expression to refined  
structure and some functional study) is no more than one third of the  
annual salary of a postdoctoral researcher; in addition, if our  
collaborator would like to apply for the funding of Chinese government (in  
conjunction with us), we can also share the funding. To projects  
practicable or really make sense the success rate of application is fairly  
acceptable.

If there is any result, our collaborator should sign the paper as  
corresponding author accordingly. To the results acquired the only right  
we reserve is that our crystallographer should sign the article as one of  
the authors. We recommend that a contract should be signed in advance to  
prevent abuse and divulgence of any sensitive information. We can from  
time to time communicate with our collaborators via email or telephone.

We will apply for our own synchrotron time in Beijing Synchrotron  
Radiation Laboratory, Beijing, China.

Generally we carry out the primary screening with Emerald Biostructures  
Wizard I/II/III, Hampton Crystal Screen kit/Crystal Screen 2 kit, Qiagen  
NeXtal Classics I / II, as well as Hampton Crystal Screen Lite,  
Sigma-Aldrich Crystallization Kit for Protein-Protein Complexes, Hampton  
Natrix, Sigma-Aldrich DNA Crystallization Kit and Sigma-Aldrich RNA  
Crystallization Kit if needed.

Thanks!

H.Y Zhang
Professor,
Life Science School,
Shandong University of Technology,
Zibo, China, 255049
Tel/Fax:  0086-533-2780271
Email: [log in to unmask]