Hi,
I posted this a little while back and haven't heard anything. If anyone
has a moment to respond, I'd appreciate it. Thanks.
I've been following some of the posts on this topic, but I wanted to make
sure I understand it.
I've collected resting-state fmri data from a patient group and a control
group. After processing the data using the pre-stats tab in FEAT and
subsequently running MELODIC, I merged the subjects' melodic outputs
together and reran MELODIC. From the resulting output, I've indentified a
number of components of interest that I'd like to compare between the two
groups.
My understanding of what I should do is the following:
1) Create a mask representing the combined thresh_zstat maps for both groups.
2) Concatenate all the thresh_zstat maps of a particular component for all
subjects, with all the subjects in one group first, followed by all the
subjects in the second.
3) Create design.mat and design.con files using the GLM Setup utility,
where my design looks like the following:
group EV1 EV2
groupA groupB Title EV1 EV2
s1 1 1 0 | C1 groupA mean 1 0
s2 1 1 0 | C2 groupB mean 0 1
s3 1 1 0 | C3 A > B 1 -1
s4 1 1 0 | C4 B > A -1 1
s5 2 0 1 |
s6 2 0 1 |
s7 2 0 1 |
s8 2 0 1 |
4) run a Two-Sample Unpaired T-test using RANDOMISE with the following
command:
randomise -i <4D_input> -o <output> -d design.mat -t design.con -c 0.99
Here are my questions:
Does it appear I am setting up the design correctly?
Is using the option "-c 0.99" the equivalent of looking for significance
at p<0.01?
Do you have any other suggestions or recommendations for carrying this out?
You help is greatly appreciated. Thanks in advance.
Cheers,
Pete
Center for Magnetic Resonance Research
University of Minnesota
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