To Whom It May Concern:
I was interested in using parametric modulation in a research study that I am currently assisting with. As this is our first time using parametric modulation, we wanted to make sure we have a good understanding of it. Our study tests changes in neural activity during a single scanning session of a spatial n-back test (3&0). During this test, we would like to see if there is a linear relationship between the brain activation and practice, as measured by time. I had the following questions about parametric modulation:
1) What kind of data does parametric modulation give? Is it a tables, images, Z-score, or some type of correlation coefficient.
2) In order to prevent signal drift in our experiment we will be using a block design alternating 3& 0 blocks. Can we use parametric modulation with a block design?
3) Do we need to first process the data using a (3-0) contrast and then apply parametric modulation, or do we use parametric modulation from the beginning without a contrast?
4) Do we have to use regions of interest of the brain in order to use parametric modulation, or do we apply it to the whole brain.
Any insight you could provide would be very helpful. Thank you very much for your time.
Collin Cannnon
University of Georgia
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