Hi Wendy,
I have no expertise in chemistry, but when I was 13 weeks pregnant had a
threatened miscarriage and was told to use paracetamol from then on for
headaches etc for the duration of the pregnancy and NOT aspirin.
I was not told why and at that stage I didn't ask many questions. Is there
any way this work could continue without specifically her involvement?
Roberta
----- Original Message -----
From: "Wendy Jones" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Thursday, April 19, 2007 5:05 PM
Subject: [OCC-HEALTH] Pregnancy risk assessment - aspirin-like substances
>I have been asked to advise on a pregnancy risk assessment for someone in
>our chemistry department. The work is based on samples of Aspirin like
>compounds, specifically those found in treatments for ulcerative colitis
>such as sulphasalazine, mesalazine and Balsalazide; and samples of Ferric
>chloride. The work will last about 5 weeks, and the pregnancy is half way
>through.
>
> Having checked the BNF, aspirin is not restricted in pregnancy,
> sulphasalazine and mesalazine are to be 'used with caution' and
> balsalazide is to be avoided. The concentrations in the experiments will
> be low - equivalent to the levels of aspirin -like compounds likely to be
> found on the urine of someone taking therapeutic doses of drugs for
> inflammatory bowel disease. On this basis my inclination is to let the
> work go ahead.
>
> I would appreciate any comments from someone with greater chemical
> expertise than me if you think I'm missing something and should be saying
> no. Incidentally they have also asked about using Mercuric Chloride in
> very small quantities and I am going to be advising against this as it has
> known reproductive effects in addition to its general high level of
> toxicity.
>
> Regards
> Wendy
>
>
> Wendy Jones
> Occupational Health Adviser
> Loughborough University
> 01509 222851
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