Hi,
We have analysed MS lesion data and, at least in the data that we
had, it seemed that TBSS was succeeding in still finding the centres
of the tracts correctly. I think (and hope) that it will generally be
the case that lesions don't affect the FA sufficiently badly that the
registration and search for tract centre is strongly affected. But it
certainly doesn't hurt to check the movie loop of the output of the
registered FA images (all_FA) underneath the thresholded skeleton.
Cheers.
On 18 Apr 2007, at 20:55, Dianne Patterson wrote:
> Hi All,
>
> I am just beginning to get my feet wet with FSL, so I would
> appreciate any thoughts on this issue as I begin to grapple with it.
>
> We are interested in the effect of white matter hyperintensities on
> white matter tract integrity. I am wondering if anyone out there
> has used TBSS to analyze white matter that has hyperintensities,
> and if those hyperintensities cause TBSS (or tractography) to lose
> the path of the white matter. If so, are there manual ways to over-
> ride this effect? (Or, maybe reasons why one would not wish to
> override it??)
>
> Thankyou,
>
> Dianne
>
> --
> Dianne Patterson, Ph.D.
> [log in to unmask]
> ERP Lab
> University of Arizona
> 621-3256 (Office)
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Stephen M. Smith, Professor of Biomedical Engineering
Associate Director, Oxford University FMRIB Centre
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+44 (0) 1865 222726 (fax 222717)
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